Dr Josie Parker

Research Highlights

1. Rybak, J., Barker, K., Muñoz, J., Parker, J., Ahmad, S., Mokaddas, E., Abdullah, A., Elhagracy, R., Kelly, S., Cuomo, C., & Rogers, P. (2022). In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris. Clinical Microbiology and Infection, 28(6), 838-843.

   https://doi.org/10.1016/j.cmi.2021.11.024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59077

   http://dx.doi.org/10.1016/j.cmi.2021.11.024
2. Aruanno, M., Gozel, S., Mouyna, I., Parker, J., Bachmann, D., Flamant, P., Coste, A., Sanglard, D., & Lamoth, F. (2021). Insights in the molecular mechanisms of an azole stress adapted laboratory-generated Aspergillus fumigatus strain. Medical Mycology, 59(8), 763-772.

   https://doi.org/10.1093/mmy/myaa118, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56258
3. Luna-Tapia, A., Parker, J., Kelly, S., & Palmer, G. (2021). Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure. Antimicrobial Agents and Chemotherapy, 65(12)

   https://doi.org/10.1128/aac.01044-21, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58450
4. Ollinger, T., Vu, B., Murante, D., Parker, J., Simonicova, L., Doorley, L., Stamnes, M., Kelly, S., Rogers, P., Moye-Rowley, W., & Krysan, D. (2021). Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis. mSphere, 6(6)

   https://doi.org/10.1128/msphere.00830-21, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59074
5. Hull, C., Bader, O., Parker, J., Weig, M., Gross, U., Warrilow, A., Kelly, D., & Kelly, S. (2012). Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations inERG2. Antimicrobial Agents and Chemotherapy, 56(12), 6417-6421.

   https://doi.org/10.1128/aac.01145-12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13028

   http://dx.doi.org/10.1128/aac.01145-12
6. Morgan, S., Pilia, N., Hewitt, M., Moses, R., Moseley, R., Lewis, P., Morrison, P., Kelly, S., Parker, J., Whitaker, D., Quantock, A., & Heard, C. (2020). Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. International Journal of Pharmaceutics, 579, 119102

   https://doi.org/10.1016/j.ijpharm.2020.119102, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53795
7. Rybak, J., Muñoz, J., Barker, K., Parker, J., Esquivel, B., Berkow, E., Lockhart, S., Gade, L., Palmer, G., White, T., Kelly, S., Cuomo, C., & Rogers, P. (2020). Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris. mBio, 11(3)

   https://doi.org/10.1128/mbio.00365-20, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54319
8. Binjubair, F., Parker, J., Warrilow, A., Puri, K., Braidley, P., Tatar, E., Kelly, S., Kelly, D., & Simons, C. (2020). Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans. ChemMedChem, 15(14), 1294-1309.

   https://doi.org/10.1002/cmdc.202000250, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54878
9. Furukawa, T., Rhijn, N., Fraczek, M., Gsaller, F., Davies, E., Carr, P., Gago, S., Fortune-Grant, R., Rahman, S., Gilsenan, J., Houlder, E., Kowalski, C., Raj, S., Paul, S., Cook, P., Parker, J., Kelly, S., Cramer, R., Latgé, J...., & Bromley, M. (2020). The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Nature Communications, 11(1)

   https://doi.org/10.1038/s41467-019-14191-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53507

   http://dx.doi.org/10.1038/s41467-019-14191-1
10. Rybak, J., Ge, W., Wiederhold, N., Parker, J., Kelly, S., Rogers, P., & Fortwendel, J. (2019). Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus. mBio, 10(2)

    https://doi.org/10.1128/mbio.00437-19, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49873
11. Warrilow, A., Nishimoto, A., Parker, J., Price, C., Flowers, S., Kelly, D., Rogers, P., & Kelly, S. (2019). The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions. Antimicrobial Agents and Chemotherapy, 63(5)

    https://doi.org/10.1128/aac.02586-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48946
12. Griffiths, W., Crick, P., Meljon, A., Theofilopoulos, S., Abdel-Khalik, J., Yutuc, E., Parker, J., Kelly, D., Kelly, S., Arenas, E., & Wang, Y. (2019). Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(2), 191-211.

    https://doi.org/10.1016/j.bbalip.2018.11.006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa46057

    http://dx.doi.org/10.1016/j.bbalip.2018.11.006
13. Warrilow, A., Parker, J., Price, C., Rolley, N., Nes, W., Kelly, D., & Kelly, S. (2019). Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens. International Journal of Antimicrobial Agents

    https://doi.org/10.1016/j.ijantimicag.2019.07.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51096
14. Ahmad, S., Joseph, L., Parker, J., Asadzadeh, M., Kelly, S., Meis, J., & Khan, Z. (2018). ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait. Antimicrobial Agents and Chemotherapy, 63(2), e01900-18

    https://doi.org/10.1128/AAC.01900-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45903
15. Zhou, W., Warrilow, A., Thomas, C., Ramos, E., Parker, J., Price, C., Vanderloop, B., Fisher, P., Loftis, M., Kelly, D., Kelly, S., & Nes, W. (2018). Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863(10), 1164-1178.

    https://doi.org/10.1016/j.bbalip.2018.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41148
16. Luna-Tapia, A., Willems, H., Parker, J., Tournu, H., Barker, K., Nishimoto, A., Rogers, P., Kelly, S., Peters, B., & Palmer, G. (2018). Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity. mBio, 9(3), e00225-18

    https://doi.org/10.1128/mBio.00225-18, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa40336
17. Colley, T., Sehra, G., Chowdhary, A., Alanio, A., Kelly, S., Kizawa, Y., Armstrong-James, D., Fisher, M., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Nishimoto, Y., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J...., & Rapeport, G. (2018). In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection. Antimicrobial Agents and Chemotherapy, 62(5), AAC.01941-17

    https://doi.org/10.1128/aac.01941-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38876

    http://dx.doi.org/10.1128/aac.01941-17
18. Butts, A., DeJarnette, C., Peters, T., Parker, J., Kerns, M., Eberle, K., Kelly, S., & Palmer, G. (2017). Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes. mSphere, 2(5), e00379-17

    https://doi.org/10.1128/mSphere.00379-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36657
19. Warrilow, A., Parker, J., Price, C., Garvey, E., Hoekstra, W., Schotzinger, R., Wiederhold, N., Nes, W., Kelly, D., & Kelly, S. (2017). The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51. Antimicrobial Agents and Chemotherapy, 61(7), e00333-17

    https://doi.org/10.1128/AAC.00333-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34176
20. Colley, T., Alanio, A., Kelly, S., Sehra, G., Kizawa, Y., Warrilow, A., Parker, J., Kelly, D., Kimura, G., Anderson-Dring, L., Nakaoki, T., Sunose, M., Onions, S., Crepin, D., Lagasse, F., Crittall, M., Shannon, J., Cooke, M., Bretagne, S...., & Rapeport, G. (2017). In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection. Antimicrobial Agents and Chemotherapy, AAC.02280-16

    https://doi.org/10.1128/AAC.02280-16, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa32189
21. Rybak, J., Dickens, C., Parker, J., Caudle, K., Manigaba, K., Whaley, S., Nishimoto, A., Luna-Tapia, A., Roy, S., Zhang, Q., Barker, K., Palmer, G., Sutter, T., Homayouni, R., Wiederhold, N., Kelly, S., & Rogers, P. (2017). Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis. Antimicrobial Agents and Chemotherapy, 61(9), AAC.00651-17

    https://doi.org/10.1128/aac.00651-17, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34548

    http://dx.doi.org/10.1128/aac.00651-17
22. Warrilow, A., Parker, J., Price, C., Nes, W., Garvey, E., Hoekstra, W., Schotzinger, R., Kelly, D., & Kelly, S. (2016). The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. Antimicrobial Agents and Chemotherapy, 60(8), 4530-4538.

    https://doi.org/10.1128/AAC.00349-16, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29154
23. Warrilow, A., Price, C., Parker, J., Rolley, N., Smyrniotis, C., Hughes, D., Thoss, V., Nes, W., Kelly, D., Holman, T., & Kelly, S. (2016). Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa. Scientific Reports, 6(1)

    https://doi.org/10.1038/srep27690, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34335
24. McCourt, P., Liu, H., Parker, J., Gallo-Ebert, C., Donigan, M., Bata, A., Giordano, C., Kelly, S., Nickels, J., & Parker, J. (2016). Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence. G3 Genes|Genomes|Genetics, 6(11)

    https://doi.org/10.1534/g3.116.033969, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31346
25. Derbyshire, M., Michaelson, L., Parker, J., Kelly, S., Thacker, U., Powers, S., Bailey, A., Hammond-Kosack, K., Courbot, M., & Rudd, J. (2015). Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genetics and Biology

    https://doi.org/10.1016/j.fgb.2015.05.008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22091
26. Berkow, E., Manigaba, K., Parker, J., Barker, K., Kelly, S., & Rogers, P. (2015). Multidrug Transporters and Alterations in Sterol Biosynthesis Contribute to Azole Antifungal Resistance in Candida parapsilosis. Antimicrobial Agents and Chemotherapy, 59(10), 5942-5950.

    https://doi.org/10.1128/aac.01358-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22523

    http://dx.doi.org/10.1128/aac.01358-15
27. Warrilow, A., Parker, J., Price, C., Nes, W., Kelly, S., & Kelly, D. (2015). In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy, 59(12), 7771-7778.

    https://doi.org/10.1128/aac.01806-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23614

    http://dx.doi.org/10.1128/aac.01806-15
28. Lamb, D., Warrilow, A., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., & Kelly, S. (2015). Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51). Antimicrobial Agents and Chemotherapy, 59(8), 4707-4713.

    https://doi.org/10.1128/AAC.00476-15, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31514

    http://aac.asm.org/content/59/8/4707.full.pdf+html
29. Price, C., Warrilow, A., Parker, J., Mullins, J., Nes, W., Kelly, D., Kelly, S., & Schottel, J. (2015). Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology, 81(10), 3379-3386.

    https://doi.org/10.1128/AEM.03965-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20704
30. Price, C., Parker, J., Warrilow, A., Kelly, D., & Kelly, S. (2015). Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens. Pest Management Science, n/a-n/a.

    https://doi.org/10.1002/ps.4029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20922
31. Warrilow, A., Hull, C., Parker, J., Garvey, E., Hoekstra, W., Moore, W., Schotzinger, R., Kelly, D., Kelly, S., & Hull, C. (2014). The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme. Antimicrobial Agents and Chemotherapy, 58(12), 7121-7127.

    https://doi.org/10.1128/AAC.03707-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18693
32. Parker, J., Warrilow, A., Price, C., Mullins, J., Kelly, D., & Kelly, S. (2014). Resistance to antifungals that target CYP51. Journal of Chemical Biology, 7(4), 143-161.

    https://doi.org/10.1007/s12154-014-0121-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18694
33. Warrilow, A., Hull, C., Rolley, N., Parker, J., Nes, W., Smith, S., Kelly, D., & Kelly, S. (2014). Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14 -Demethylase (CYP51). Applied and Environmental Microbiology, 80(19), 6154-6166.

    https://doi.org/10.1128/AEM.01195-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18616
34. Fan, J., Urban, M., Parker, J., Brewer, H., Kelly, S., Hammond-Kosack, K., Fraaije, B., Liu, X., & Cools, H. (2013). Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function. New Phytologist-n/a.

    https://doi.org/10.1111/NPH.12193, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14421
35. Kelly, S., Kelly, D., Parker, J., & Warrilow, A. (2013). Azole Affinity of Sterol 14alpha-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens. Antimicrobial Agents and Chemotherapy, 57(3)-1360.

    https://doi.org/10.1128/AAC.02067-12, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14415
36. Eddouzi, J., Parker, J., Vale-Silva, L., Coste, A., Ischer, F., Kelly, S., Manai, M., & Sanglard, D. (2013). Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals. Antimicrobial Agents and Chemotherapy, 57(7), 3182-3193.

    https://doi.org/10.1128/AAC.00555-13, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15187
37. Nie, D., Hoobler, E., Rai, G., Warrilow, A., Perry, S., Smyrniotis, C., Jadhav, A., Simeonov, A., Parker, J., Kelly, D., Maloney, D., Kelly, S., & Holman, T. (2013). Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy. PLoS ONE, 8(6)

    https://doi.org/10.1371/journal.pone.0065928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa15178
38. Vale-Silva, L., Coste, A., Ischer, F., Parker, J., Kelly, S., Pinto, E., & Sanglard, D. (2012). Azole Resistance by Loss of Function of the Sterol Δ5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence. Antimicrobial Agents and Chemotherapy, 56(4), 1960-1968.

    https://doi.org/10.1128/aac.05720-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6836
39. Hull, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., & Kelly, S. (2012). Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation inERG11and Exhibiting Cross-Resistance to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy, 56(8), 4223-4232.

    https://doi.org/10.1128/aac.06253-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12338

    http://dx.doi.org/10.1128/aac.06253-11
40. Cools, H., Mullins, J., Fraaije, B., Parker, J., Kelly, D., Lucas, J., & Kelly, S. (2011). Impact of Recently Emerged Sterol 14 alpha-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology, 77(11), 3830-3837.

    https://doi.org/10.1128/AEM.00027-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6846
41. Mullins, J., Parker, J., Cools, H., Togawa, R., Lucas, J., Fraaije, B., Kelly, D., & Kelly, S. (2011). Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola. PLoS ONE, 6(6), e20973

    https://doi.org/10.1371/journal.pone.0020973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6839
42. Martel, C., Parker, J., Jackson, C., Warrilow, A., Rolley, N., Greig, C., Morris, S., Donnison, I., Kelly, D., Kelly, S., & Hull, C. (2011). Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol. Bioresource Technology, 102(2), 1503-1508.

    https://doi.org/10.1016/j.biortech.2010.07.099, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6360
43. Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Rolley, N., Kelly, D., Kelly, S., & Hull, C. (2010). Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans. Antimicrobial Agents and Chemotherapy, 54(11), 4527-4533.

    https://doi.org/10.1128/AAC.00348-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6358
44. Cools, H., Parker, J., Kelly, D., Lucas, J., Fraaije, B., & Kelly, S. (2010). Heterologous Expression of Mutated Eburicol 14α-Demethylase (CYP51) Proteins of Mycosphaerella graminicola To Assess Effects on Azole Fungicide Sensitivity and Intrinsic Protein Function. Applied and Environmental Microbiology, 76(9), 2866-2872.

    https://doi.org/10.1128/aem.02158-09, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6856

    http://dx.doi.org/10.1128/aem.02158-09
45. Warrilow, A., Melo, N., Martel, C., Parker, J., Nes, W., Kelly, S., & Kelly, D. (2010). Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14alpha-Demethylase (CYP51) Isoenzymes A and B. Antimicrobial Agents and Chemotherapy, 54(10), 4225-4234.

    https://doi.org/10.1128/AAC.00316-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6354
46. Martel, C., Parker, J., Bader, O., Weig, M., Gross, U., Warrilow, A., Kelly, D., Kelly, S., Parker, J., & Hull, C. (2010). A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14alpha-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B. Antimicrobial Agents and Chemotherapy, 54(9), 3578-3583.

    https://doi.org/10.1128/AAC.00303-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6353
47. Warrilow, A., Martel, C., Parker, J., Melo, N., Lamb, D., Nes, W., Kelly, D., Kelly, S., & Hull, C. (2010). Azole Binding Properties of Candida albicans Sterol 14alpha-Demethylase (CaCYP51). Antimicrobial Agents and Chemotherapy, 54(10), 4235-4245.

    https://doi.org/10.1128/AAC.00587-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6355
48. Martel, C., Parker, J., Warrilow, A., Rolley, N., Kelly, S., Kelly, D., Parker, J., Hull, C., & Warrilow, A. (2010). Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14alpha-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B. Antimicrobial Agents and Chemotherapy, 54(11), 4920-4923.

    https://doi.org/10.1128/AAC.00349-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6356
49. Martel, C., Warrilow, A., Jackson, C., Mullins, J., Togawa, R., Parker, J., Morris, M., Donnison, I., Kelly, D., Kelly, S., Mullins, J., & Hull, C. (2010). Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans. Bioresource Technology, 101(12), 4395-4402.

    https://doi.org/10.1016/j.biortech.2010.01.084, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6359
50. Parker, J., Warrilow, A., Cools, H., Martel, C., Nes, W., Fraaije, B., Lucas, J., Kelly, D., Kelly, S., & Hull, C. (2010). Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals. Applied and Environmental Microbiology, 77(4), 1460-1465.

    https://doi.org/10.1128/AEM.01332-10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6361
51. Parker, J., Merkamm, M., Manning, N., Pompon, D., Kelly, S., & Kelly, D. (2008). Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14 alpha-Demethylase at the Homologous Locus. Antimicrobial Agents and Chemotherapy, 52(10), 3597-3603.

    https://doi.org/10.1128/AAC.00517-08, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6835
52. Warrilow, A., Jackson, C., Parker, J., Marczylo, T., Kelly, D., Lamb, D., & Kelly, S. (2008). Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae. Antimicrobial Agents and Chemotherapy, 53(3), 1157-1164.

    https://doi.org/10.1128/AAC.01237-08, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6351
53. Jackson, C., Lamb, D., Marczylo, T., Parker, J., Manning, N., Kelly, D., & Kelly, S. (2003). Conservation and cloning of CYP51: a sterol 14α-demethylase from Mycobacterium smegmatis. Biochemical and Biophysical Research Communications, 301(2), 558

    https://doi.org/10.1016/S0006-291X(02)03078-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6859
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