Dr Spyridon Zisimopoulos

Associate Professor

Biomedical Sciences

spyros.zissimopoulos@swansea.ac.uk

Available For Postgraduate Supervision

Research Links

https://orcid.org/0000-0001-5196-9450

ResearchGate

About

Spyros is a British Heart Foundation Senior Research Fellow and Associate Professor with 20 years research experience in excitation-contraction coupling and calcium signalling. Spyros obtained a BSc in Chemistry from the University of Athens, Greece, and an MSc in Biochemistry & Molecular Biology from King’s College London. He was awarded a PhD from the University of Wales College of Medicine for the characterisation of the ryanodine receptor calcium release channel complex. Spyros was based for several years in the Wales Heart Research Institute, Cardiff, with like-minded researchers (Tony Lai, Alan Williams, Chris George, Lowri Thomas) to acquire and expand his expertise in bioinformatics, molecular biology, biochemistry, biophysical single channel characterisation, fluorescence and confocal microscopy. Spyros’ independent career was kickstarted by a BHF Intermediate Research Fellowship in 2009 and was consolidated by a BHF Senior Research Fellowship in 2015. He has been in Swansea Medical School since 2017 and was appointed as an Associate Professor in 2020.

Spyros’ main research is on the structure-function analysis of the ryanodine receptor calcium release channel and its role in arrhythmias and sudden cardiac death. A particular ambition is the identification of novel anti-arrhythmic drugs that specifically target and stabilise ryanodine receptor function.

Areas Of Expertise

Calcium signalling
Excitation-contraction coupling
Molecular mechanisms of disease
Protein-protein interactions
Calcium release channel activity

Career Highlights

Teaching Interests

Spyros has supervised several PGR students at both the MSc and PhD level. He is also actively contributing to teaching on the Applied Medical Sciences BSc programme.

Research Award Highlights Collaborations

Publications

Research Highlights

ZHANG, Y., Rabesahala de Meritens, C., Beckmann, A., Lai, F., & Zisimopoulos, S. (2022). Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders. Frontiers in Physiology, 13
https://doi.org/10.3389/fphys.2022.1032132, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62166
Patel, S., Zisimopoulos, S., & Marchant, J. (2022). Endo-Lysosomal Two-Pore Channels and Their Protein Partners. Handbook of Experimental Pharmacology Springer Berlin Heidelberg
https://doi.org/10.1007/164_2022_601, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62165
Fowler, E. & Zisimopoulos, S. (2022). Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease. Biomolecules, 12(8), 1030
https://doi.org/10.3390/biom12081030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62164
Yin, L., Zahradnikova, A., Rizzetto, R., Boncompagni, S., Rabesahala de Meritens, C., ZHANG, Y., Joanne, P., Marqués-Sulé, E., Aguilar-Sánchez, Y., Fernández-Tenorio, M., Villejoubert, O., Li, L., Wang, Y., Mateo, P., Nicolas, V., Gerbaud, P., Lai, F., Perrier, R., Álvarez, J...., & Gómez, A. (2021). Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation. Circulation Research, 129(3), e35-e52.
https://doi.org/10.1161/circresaha.121.319094, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57636
http://dx.doi.org/10.1161/circresaha.121.319094
Seidel, M., Rabesahala de Meritens, C., Johnson, L., Parthimos, D., Bannister, M., Thomas, N., Ozekhome-Mike, E., Lai, F., & Zisimopoulos, S. (2021). Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. Cardiovascular Research, 117(3), 780-791.
https://doi.org/10.1093/cvr/cvaa043, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53861
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2018). Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?. Journal of Cell Science, 131(15), jcs210443
https://doi.org/10.1242/jcs.210443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41186
Handhle, A., Ormonde, C., Thomas, N., Bralesford, C., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., & Zisimopoulos, S. (2016). Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science, jcs.191643
https://doi.org/10.1242/jcs.191643, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35345
http://www.scopus.com/inward/record.url?eid=2-s2.0-84995529372&partnerID=MN8TOARS
Stanczyk, P., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2016). Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study. Journal of Visualized Experiments(113)
https://doi.org/10.3791/54271, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36630
Seidel, M., Thomas, N., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., Zisimopoulos, S., & Williams, A. (2015). Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research, 105(1), 118-128.
https://doi.org/10.1093/cvr/cvu240, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35341
http://www.scopus.com/inward/record.url?eid=2-s2.0-84929081932&partnerID=MN8TOARS
Domingo, D., Neco, P., Fernández-Pons, E., Zissimopoulos, S., Molina, P., Olagüe, J., Suárez-Mier, M., Lai, F., Gómez, A., Zorio, E., & Zisimopoulos, S. (2015). Non-ventricular, Clinical, and Functional Features of the RyR2R420Q Mutation Causing Catecholaminergic Polymorphic Ventricular Tachycardia. Revista Española de Cardiología (English Edition), 68(5), 398-407.
https://doi.org/10.1016/j.rec.2014.04.023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36632
Seidel, M., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2015). Structural and functional interactions within ryanodine receptor. Biochemical Society Transactions, 43(3), 377-383.
https://doi.org/10.1042/BST20140292, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36631
Ljubojevic, S., Radulovic, S., Leitinger, G., Sedej, S., Sacherer, M., Holzer, M., Winkler, C., Pritz, E., Mittler, T., Schmidt, A., Sereinigg, M., Wakula, P., Zissimopoulos, S., Bisping, E., Post, H., Marsche, G., Bossuyt, J., Bers, D., Kockskamper, J...., & Zisimopoulos, S. (2014). Early Remodeling of Perinuclear Ca2+ Stores and Nucleoplasmic Ca2+ Signaling During the Development of Hypertrophy and Heart Failure. Circulation, 130(3), 244-255.
https://doi.org/10.1161/CIRCULATIONAHA.114.008927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36634
Zissimopoulos, S., Marsh, J., Stannard, L., Seidel, M., Lai, F., & Zisimopoulos, S. (2014). N-terminus oligomerization is conserved in intracellular calcium release channels. Biochemical Journal, 459(2), 265-273.
https://doi.org/10.1042/BJ20131061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36635
Lam, A., Galione, A., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2013). Hax-1 identified as a two-pore channel (TPC)-binding protein. FEBS Letters, 587(23), 3782-3786.
https://doi.org/10.1016/j.febslet.2013.10.031, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36639
Zissimopoulos, S., Viero, C., Seidel, M., Cumbes, B., White, J., Cheung, I., Stewart, R., Jeyakumar, L., Fleischer, S., Mukherjee, S., Lowri Thomas, N., Williams, A., Anthony Lai, F., Cumbes, B., Thomas, N., Zisimopoulos, S., Mukherjee, S., & Williams, A. (2013). N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science, 126(21), 5042-5051.
https://doi.org/10.1242/jcs.133538, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34390
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887595981&partnerID=MN8TOARS
Zissimopoulos, S., Seifan, S., Maxwell, C., Williams, A., Lai, F., Zisimopoulos, S., & Williams, A. (2012). Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. Journal of Cell Science, 125(7), 1759-1769.
https://doi.org/10.1242/jcs.098012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35915
Zissimopoulos, S., Thomas, N., Jamaluddin, W., Lai, F., Thomas, N., & Zisimopoulos, S. (2009). FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal, 419(2), 273-278.
https://doi.org/10.1042/BJ20082324, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35332
http://www.scopus.com/inward/record.url?eid=2-s2.0-64249111141&partnerID=MN8TOARS
Gomez, A., Rueda, A., Sainte-Marie, Y., Pereira, L., Zissimopoulos, S., Zhu, X., Schaub, R., Perrier, E., Perrier, R., Latouche, C., Richard, S., Picot, M., Jaisser, F., Lai, F., Valdivia, H., Benitah, J., & Zisimopoulos, S. (2009). Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins. Circulation, 119(16), 2179-2187.
https://doi.org/10.1161/CIRCULATIONAHA.108.805804, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36642
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2007). Ryanodine receptor structure, function and pathophysiology. Calcium - A Matter of Life or Death (pp. 287-342). Elsevier
https://doi.org/10.1016/S0167-7306(06)41012-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36654
http://www.sciencedirect.com/science/article/pii/S0167730606410127
Zissimopoulos, S., Docrat, N., Lai, F., & Zisimopoulos, S. (2007). Redox Sensitivity of the Ryanodine Receptor Interaction with FK506-binding Protein. Journal of Biological Chemistry, 282(10), 6976-6983.
https://doi.org/10.1074/jbc.M607590200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36644
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2006). Redox regulation of the ryanodine receptor/calcium release channel. Biochemical Society Transactions, 34(5), 919-921.
https://doi.org/10.1042/BST0340919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36645
Liu, N. & Zisimopoulos, S. (2006). Arrhythmogenesis in Catecholaminergic Polymorphic Ventricular Tachycardia: Insights From a RyR2 R4496C Knock-In Mouse Model. Circulation Research, 99(3), 292-298.
https://doi.org/10.1161/01.RES.0000235869.50747.e1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36646
De Crescenzo, V., Fogarty, K., ZhuGe, R., Tuft, R., Lifshitz, L., Carmichael, J., Bellve, K., Baker, S., Zissimopoulos, S., Lai, F., Lemos, J., Walsh, J., & Zisimopoulos, S. (2006). Dihydropyridine Receptors and Type 1 Ryanodine Receptors Constitute the Molecular Machinery for Voltage-Induced Ca2+ Release in Nerve Terminals. Journal of Neuroscience, 26(29), 7565-7574.
https://doi.org/10.1523/JNEUROSCI.1512-06.2006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36647
Zisimopoulos, S., West, D., Williams, A., & Lai, F. (2006). Ryanodine receptor interaction with the SNARE-associated protein snapin. Journal of Cell Science, 119(11), 2386-2397.
https://doi.org/10.1242/jcs.02936, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35574
http://europepmc.org/abstract/med/16723744
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Interaction of FKBP12.6 with the Cardiac Ryanodine Receptor C-terminal Domain. Journal of Biological Chemistry, 280(7), 5475-5485.
https://doi.org/10.1074/jbc.M412954200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36649
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Central Domain of the Human Cardiac Muscle Ryanodine Receptor Does Not Mediate Interaction With FKBP12.6. Cell Biochemistry and Biophysics, 43(2), 203-220.
https://doi.org/10.1385/CBB:43:2:203, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36650
Blayney, L., Zissimopoulos, S., Ralph, E., Abbot, E., Matthews, L., Lai, F., & Zisimopoulos, S. (2004). Ryanodine Receptor Oligomeric Interaction. Journal of Biological Chemistry, 279(15), 14639-14648.
https://doi.org/10.1074/jbc.M308014200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36651
STEWART, R., ZISSIMOPOULOS, S., LAI, F., & Zisimopoulos, S. (2003). Oligomerization of the cardiac ryanodine receptor C-terminal tail. Biochemical Journal, 376(3), 795-799.
https://doi.org/10.1042/BJ20030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36652

All Research

Journal Articles

ZHANG, Y., Rabesahala de Meritens, C., Beckmann, A., Lai, F., & Zisimopoulos, S. (2022). Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders. Frontiers in Physiology, 13
https://doi.org/10.3389/fphys.2022.1032132, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62166
Fowler, E. & Zisimopoulos, S. (2022). Molecular, Subcellular, and Arrhythmogenic Mechanisms in Genetic RyR2 Disease. Biomolecules, 12(8), 1030
https://doi.org/10.3390/biom12081030, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62164
Yin, L., Zahradnikova, A., Rizzetto, R., Boncompagni, S., Rabesahala de Meritens, C., ZHANG, Y., Joanne, P., Marqués-Sulé, E., Aguilar-Sánchez, Y., Fernández-Tenorio, M., Villejoubert, O., Li, L., Wang, Y., Mateo, P., Nicolas, V., Gerbaud, P., Lai, F., Perrier, R., Álvarez, J...., & Gómez, A. (2021). Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation. Circulation Research, 129(3), e35-e52.
https://doi.org/10.1161/circresaha.121.319094, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57636
http://dx.doi.org/10.1161/circresaha.121.319094
Seidel, M., Rabesahala de Meritens, C., Johnson, L., Parthimos, D., Bannister, M., Thomas, N., Ozekhome-Mike, E., Lai, F., & Zisimopoulos, S. (2021). Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function. Cardiovascular Research, 117(3), 780-791.
https://doi.org/10.1093/cvr/cvaa043, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53861
Stanczyk, P., Seidel, M., White, J., Viero, C., George, C., Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2018). Association of cardiac myosin-binding protein-C with the ryanodine receptor channel – putative retrograde regulation?. Journal of Cell Science, 131(15), jcs210443
https://doi.org/10.1242/jcs.210443, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa41186
Handhle, A., Ormonde, C., Thomas, N., Bralesford, C., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., & Zisimopoulos, S. (2016). Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science, jcs.191643
https://doi.org/10.1242/jcs.191643, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35345
http://www.scopus.com/inward/record.url?eid=2-s2.0-84995529372&partnerID=MN8TOARS
Stanczyk, P., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2016). Genetic and Biochemical Approaches for In Vivo and In Vitro Assessment of Protein Oligomerization: The Ryanodine Receptor Case Study. Journal of Visualized Experiments(113)
https://doi.org/10.3791/54271, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36630
Seidel, M., Thomas, N., Williams, A., Lai, F., Zissimopoulos, S., Thomas, N., Zisimopoulos, S., & Williams, A. (2015). Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors. Cardiovascular Research, 105(1), 118-128.
https://doi.org/10.1093/cvr/cvu240, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35341
http://www.scopus.com/inward/record.url?eid=2-s2.0-84929081932&partnerID=MN8TOARS
Domingo, D., Neco, P., Fernández-Pons, E., Zissimopoulos, S., Molina, P., Olagüe, J., Suárez-Mier, M., Lai, F., Gómez, A., Zorio, E., & Zisimopoulos, S. (2015). Non-ventricular, Clinical, and Functional Features of the RyR2R420Q Mutation Causing Catecholaminergic Polymorphic Ventricular Tachycardia. Revista Española de Cardiología (English Edition), 68(5), 398-407.
https://doi.org/10.1016/j.rec.2014.04.023, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36632
Seidel, M., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2015). Structural and functional interactions within ryanodine receptor. Biochemical Society Transactions, 43(3), 377-383.
https://doi.org/10.1042/BST20140292, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36631
Ljubojevic, S., Radulovic, S., Leitinger, G., Sedej, S., Sacherer, M., Holzer, M., Winkler, C., Pritz, E., Mittler, T., Schmidt, A., Sereinigg, M., Wakula, P., Zissimopoulos, S., Bisping, E., Post, H., Marsche, G., Bossuyt, J., Bers, D., Kockskamper, J...., & Zisimopoulos, S. (2014). Early Remodeling of Perinuclear Ca2+ Stores and Nucleoplasmic Ca2+ Signaling During the Development of Hypertrophy and Heart Failure. Circulation, 130(3), 244-255.
https://doi.org/10.1161/CIRCULATIONAHA.114.008927, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36634
Zissimopoulos, S., Marsh, J., Stannard, L., Seidel, M., Lai, F., & Zisimopoulos, S. (2014). N-terminus oligomerization is conserved in intracellular calcium release channels. Biochemical Journal, 459(2), 265-273.
https://doi.org/10.1042/BJ20131061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36635
Lam, A., Galione, A., Lai, F., Zissimopoulos, S., & Zisimopoulos, S. (2013). Hax-1 identified as a two-pore channel (TPC)-binding protein. FEBS Letters, 587(23), 3782-3786.
https://doi.org/10.1016/j.febslet.2013.10.031, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36639
Zissimopoulos, S., Viero, C., Seidel, M., Cumbes, B., White, J., Cheung, I., Stewart, R., Jeyakumar, L., Fleischer, S., Mukherjee, S., Lowri Thomas, N., Williams, A., Anthony Lai, F., Cumbes, B., Thomas, N., Zisimopoulos, S., Mukherjee, S., & Williams, A. (2013). N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science, 126(21), 5042-5051.
https://doi.org/10.1242/jcs.133538, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34390
http://www.scopus.com/inward/record.url?eid=2-s2.0-84887595981&partnerID=MN8TOARS
Zissimopoulos, S., Seifan, S., Maxwell, C., Williams, A., Lai, F., Zisimopoulos, S., & Williams, A. (2012). Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. Journal of Cell Science, 125(7), 1759-1769.
https://doi.org/10.1242/jcs.098012, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35915
Zissimopoulos, S., Thomas, N., Jamaluddin, W., Lai, F., Thomas, N., & Zisimopoulos, S. (2009). FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochemical Journal, 419(2), 273-278.
https://doi.org/10.1042/BJ20082324, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35332
http://www.scopus.com/inward/record.url?eid=2-s2.0-64249111141&partnerID=MN8TOARS
Gomez, A., Rueda, A., Sainte-Marie, Y., Pereira, L., Zissimopoulos, S., Zhu, X., Schaub, R., Perrier, E., Perrier, R., Latouche, C., Richard, S., Picot, M., Jaisser, F., Lai, F., Valdivia, H., Benitah, J., & Zisimopoulos, S. (2009). Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins. Circulation, 119(16), 2179-2187.
https://doi.org/10.1161/CIRCULATIONAHA.108.805804, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36642
Zissimopoulos, S., Docrat, N., Lai, F., & Zisimopoulos, S. (2007). Redox Sensitivity of the Ryanodine Receptor Interaction with FK506-binding Protein. Journal of Biological Chemistry, 282(10), 6976-6983.
https://doi.org/10.1074/jbc.M607590200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36644
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2006). Redox regulation of the ryanodine receptor/calcium release channel. Biochemical Society Transactions, 34(5), 919-921.
https://doi.org/10.1042/BST0340919, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36645
Liu, N. & Zisimopoulos, S. (2006). Arrhythmogenesis in Catecholaminergic Polymorphic Ventricular Tachycardia: Insights From a RyR2 R4496C Knock-In Mouse Model. Circulation Research, 99(3), 292-298.
https://doi.org/10.1161/01.RES.0000235869.50747.e1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36646
De Crescenzo, V., Fogarty, K., ZhuGe, R., Tuft, R., Lifshitz, L., Carmichael, J., Bellve, K., Baker, S., Zissimopoulos, S., Lai, F., Lemos, J., Walsh, J., & Zisimopoulos, S. (2006). Dihydropyridine Receptors and Type 1 Ryanodine Receptors Constitute the Molecular Machinery for Voltage-Induced Ca2+ Release in Nerve Terminals. Journal of Neuroscience, 26(29), 7565-7574.
https://doi.org/10.1523/JNEUROSCI.1512-06.2006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36647
Zisimopoulos, S., West, D., Williams, A., & Lai, F. (2006). Ryanodine receptor interaction with the SNARE-associated protein snapin. Journal of Cell Science, 119(11), 2386-2397.
https://doi.org/10.1242/jcs.02936, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa35574
http://europepmc.org/abstract/med/16723744
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Interaction of FKBP12.6 with the Cardiac Ryanodine Receptor C-terminal Domain. Journal of Biological Chemistry, 280(7), 5475-5485.
https://doi.org/10.1074/jbc.M412954200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36649
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2005). Central Domain of the Human Cardiac Muscle Ryanodine Receptor Does Not Mediate Interaction With FKBP12.6. Cell Biochemistry and Biophysics, 43(2), 203-220.
https://doi.org/10.1385/CBB:43:2:203, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36650
Blayney, L., Zissimopoulos, S., Ralph, E., Abbot, E., Matthews, L., Lai, F., & Zisimopoulos, S. (2004). Ryanodine Receptor Oligomeric Interaction. Journal of Biological Chemistry, 279(15), 14639-14648.
https://doi.org/10.1074/jbc.M308014200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36651
STEWART, R., ZISSIMOPOULOS, S., LAI, F., & Zisimopoulos, S. (2003). Oligomerization of the cardiac ryanodine receptor C-terminal tail. Biochemical Journal, 376(3), 795-799.
https://doi.org/10.1042/BJ20030597, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36652

Book Chapters

Patel, S., Zisimopoulos, S., & Marchant, J. (2022). Endo-Lysosomal Two-Pore Channels and Their Protein Partners. Handbook of Experimental Pharmacology Springer Berlin Heidelberg
https://doi.org/10.1007/164_2022_601, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62165
Zissimopoulos, S., Lai, F., & Zisimopoulos, S. (2007). Ryanodine receptor structure, function and pathophysiology. Calcium - A Matter of Life or Death (pp. 287-342). Elsevier
https://doi.org/10.1016/S0167-7306(06)41012-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36654
http://www.sciencedirect.com/science/article/pii/S0167730606410127

Taught Modules

PM-130 Fundamental Research Skills

This module is designed to develop the skills required for students of biochemistry and genetics degree programmes. Students meet with their tutors and will be given a series of assignments designed to develop skills in key areas such as essay writing, presentations and general numeracy.
PMRM04 Dissertation (Research)

This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study.

Key Grants and Projects

Drug-induced stabilisation of RyR2 to improve calcium handling and cardiac function in arrhythmogenic cardiac disease 2015 - 2020

BHF Senior Research Fellowship , with Dr Yadan Zhang, Ms Astrid Beckmann, Mr Jake Evans , £1,029,695