Dr Feihu Zhao

Darlithydd ZCCE (IMPACT)

Biomedical Engineering

feihu.zhao@abertawe.ac.uk

Swyddfa Academaidd - A_202
Ail lawr
Adeilad Canolog Peirianneg
Campws y Bae

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0003-0515-6808

Trosolwg

Mae Dr Feihu Zhao yn Ddarlithydd Peirianneg Fiofeddygol yng Nghanolfan Peirianneg Gyfrifiadol Zienkiewicz (ZCCE), y Coleg Peirianneg, Prifysgol Abertawe. Cyn ymuno â Phrifysgol Abertawe, bu Feihu yn Ymchwilydd Ôl-ddoethurol mewn Biomecaneg Orthopedig, yn Adran Peirianneg Fiofeddygol Prifysgol Technoleg Eindhoven yn yr Iseldiroedd. Yn ystod ei gyfnod ôl-ddoethurol, bu gan Feihu swydd Ymwelydd Academydd hefyd yn Sefydliad INSIGNEO ar gyfer Meddygaeth in silico, Prifysgol Sheffield, o fis Ebrill 2017 tan fis Gorffennaf 2017. Derbyniodd Feihu ei radd PhD mewn Peirianneg Fiofeddygol gan Brifysgol Genedlaethol Iwerddon, Galway, Iwerddon yn 2016, a gradd MSc (Tech.) mewn Awtomatiaeth Peiriannau gan Brifysgol Technoleg Tampere, y Ffindir yn 2012.

Mae ymchwil Feihu yn canolbwyntio’n bennaf ar ddefnyddio dulliau in silico i egluro ac optimeiddio amgylchedd micro-fecanyddol celloedd ar gyfer peirianneg esgyrn a meinweoedd cartilag. Mae ei ymchwil hefyd yn cynnwys defnyddio cyfuniad o dechnegau cyfrifiadol ac arbrofol (e.e. microsgopeg grym atomig, micro-hylifeg) i ymchwilio i fiomecaneg a mecanofioleg celloedd. Mae ei ymchwil wedi darparu gwybodaeth bwysig ar gyfer ymchwil a datblygu ym maes cynhyrchion peirianneg meinweoedd (e.e. sgaffaldau bioddeunyddiau, bioadweithyddion a sglodion meinwe) ar gyfer aildyfu esgyrn a chartilag.

Meysydd Arbenigedd

Peirianneg meinweoedd in silico
Biomecaneg gellog a mecanofioleg
Dylunio dyfeisiau biofeddygol

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

EGA163 – Dosbarthiadau Dylunio a Labordy 1/EG236 – Dylunio ar gyfer Peirianneg Feddygol

EG262 – Dadansoddi Diriant

EGA308 – Technoleg Mewnblaniadau a Phrosthetigau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Kreutzer, J., Viehrig, M., Pölönen, R., Zhao, F., Ojala, M., Aalto-Setälä, K., & Kallio, P. (2019). Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes. Biomechanics and Modeling in Mechanobiology
https://doi.org/10.1007/s10237-019-01211-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51678
Zhao, F., Melke, J., Ito, K., Rietbergen, B., & Hofmann, S. (2019). A multiscale computational fluid dynamics approach to simulate the micro-fluidic environment within a tissue engineering scaffold with highly irregular pore geometry. Biomechanics and Modeling in Mechanobiology, 18
https://doi.org/10.1007/s10237-019-01188-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51679
Qu, Y., Zhao, F., Wang, X., Liu, J., Li, J., Song, Z., & Wang, Z. (2019). Cardiomyocyte contractile force changes in response to AGRWE detected by AFM. Micro & Nano Letters, 14(5), 511-514.
https://doi.org/10.1049/mnl.2018.5458, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51680
Zhao, F., Rietbergen, B., Ito, K., & Hofmann, S. (2018). Flow rates in perfusion bioreactors to maximise mineralisation in bone tissue engineering in vitro. Journal of Biomechanics, 79, 232-237.
https://doi.org/10.1016/j.jbiomech.2018.08.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51681
Melke, J., Zhao, F., Rietbergen, B., Ito, K., & Hofmann, S. (2018). Localisation of mineralised tissue in a complex spinner flask environment correlates with predicted wall shear stress level localisation. European Cells and Materials, 36, 57-68.
https://doi.org/10.22203/eCM.v036a05, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51682
http://www.ecmjournal.org/papers/vol036/vol036a05.php
Qu, Y., Wang, Z., Zhao, F., Liu, J., Zhang, W., Li, J., Song, Z., & Xu, H. (2018). AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract. Micron, 104, 1-7.
https://doi.org/10.1016/j.micron.2017.10.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51683
Zhao, F., Garrigle, M., Vaughan, T., & McNamara, L. (2018). In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm. Biomechanics and Modeling in Mechanobiology, 17(1), 5-18.
https://doi.org/10.1007/s10237-017-0941-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51684
Zhao, F., Vaughan, T., Mc Garrigle, M., & McNamara, L. (2017). A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading. Computers in Biology and Medicine, 89, 181-189.
https://doi.org/10.1016/j.compbiomed.2017.08.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51685
Qian, W., Qi, L., Xu, L., He, Y., Zhao, F., & Sun, Y. (2017). Finite element analysis of a new type of post dilatation ballon catheter in PCI. In 5th international conference on Computational and Mathematical Biomedical Engineering, CMBE 20175th International Conference on Computational & Mathematical Biomedical Engineering (CMBE2017).
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51686
Virjula, S., Zhao, F., Leivo, J., Vanhatupa, S., Kreutzer, J., Vaughan, T., Honkala, A., Viehrig, M., Mullen, C., Kallio, P., McNamara, L., & Miettinen, S. (2017). The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells. Journal of the Mechanical Behavior of Biomedical Materials, 72, 38-48.
https://doi.org/10.1016/j.jmbbm.2017.04.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51687
Zhao, F. (2016). In silico bone tissue engineering-a multiscale and multiphysics approach
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51688
Zhao, F., Vaughan, T., & McNamara, L. (2015). Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures. Biomechanics and Modeling in Mechanobiology, 15(3), 561-577.
https://doi.org/10.1007/s10237-015-0710-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51689
Zhao, F., Kreutzer, J., Pajunen, S., & Kallio, P. (2014). Mechanical Analysis of a Pneumatically Actuated Concentric Double-Shell Structure for Cell Stretching. Micromachines, 5(4), 868-885.
https://doi.org/10.3390/mi5040868, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51690
Zhao, F., Kreutzer, J., & Kallio, P. (2014). Computational modeling and structural improvement of a pneumatically actuated concentric double-shell structure for cell stretching.
https://doi.org/10.1109/ICMA.2014.6885818, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51691
Zhao, F., Vaughan, T., & Mcnamara, L. (2015). Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold. Biomechanics and Modeling in Mechanobiology, 14(2), 231-243.
https://doi.org/10.1007/s10237-014-0599-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51692
Hu, K., Zhao, F., & Wang, Q. (2013). Mechanical characterization of living and dead undifferentiated human adipose-derived stem cells by using atomic force microscopy. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 227(12), 1319-1323.
https://doi.org/10.1177/0954411913503064, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51693
Zhao, F. (2012). Modelling of Three Dimensional Elastomer Structures for Cell Stimulation Using Finite Element Method
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51694
Zhao, F., Lacroix, D., Ito, K., Rietbergen, B., & Hofmann, S. (2020). Changes in scaffold porosity during bone tissue engineering in perfusion bioreactors considerably affect cellular mechanical stimulation for mineralization. Bone Reports, 12, 100265
https://doi.org/10.1016/j.bonr.2020.100265, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53924
Driessen, R., Zhao, F., Hofmann, S., Bouten, C., Sahlgren, C., & Stassen, O. (2020). Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker. Micromachines, 11(6), 552
https://doi.org/10.3390/mi11060552, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54857
Zhao, F., Rietbergen, B., Ito, K., & Hofmann, S. (2020). Fluid flow‐induced cell stimulation in bone tissue engineering changes due to interstitial tissue formation in vitro. International Journal for Numerical Methods in Biomedical Engineering, 36(6)
https://doi.org/10.1002/cnm.3342, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55894
Melke, J., Zhao, F., Ito, K., & Hofmann, S. (2020). Orbital seeding of mesenchymal stromal cells increases osteogenic differentiation and bone‐like tissue formation. Journal of Orthopaedic Research, 38(6), 1228-1237.
https://doi.org/10.1002/jor.24583, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55895
Akiva, A., Melke, J., Ansari, S., Liv, N., Meijden, R., Erp, M., Zhao, F., Stout, M., Nijhuis, W., Heus, C., Ortera, C., Fermie, J., Klumperman, J., Ito, K., Sommerdijk, N., & Hofmann, S. (2021). An Organoid for Woven Bone. Advanced Functional Materials, 31(17), 2010524
https://doi.org/10.1002/adfm.202010524, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56465
http://dx.doi.org/10.1002/adfm.202010524
Qi, L., Zhu, W., Qian, W., Xu, L., He, Y., & Zhao, F. (2021). The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments. Frontiers in Physiology, 12
https://doi.org/10.3389/fphys.2021.734565, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57927
Rubert, M., Vetsch, J., Lehtoviita, I., Sommer, M., Zhao, F., Studart, A., Müller, R., & Hofmann, S. (2021). Scaffold Pore Geometry Guides Gene Regulation and Bone-like Tissue Formation in Dynamic Cultures. Tissue Engineering Part A, 27(17-18), 1192-1204.
https://doi.org/10.1089/ten.tea.2020.0121, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58125
Zhao, F., Xiong, Y., Ito, K., Rietbergen, B., & Hofmann, S. (2021). Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering. Frontiers in Bioengineering and Biotechnology, 9, 736489
https://doi.org/10.3389/fbioe.2021.736489, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58151
Ahmed, H., Bedding-Tyrrell, M., Deganello, D., Xia, Z., Xiong, Y., & Zhao, F. (2023). Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model. Medicine in Novel Technology and Devices, 18, 100223
https://doi.org/10.1016/j.medntd.2023.100223, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62890
http://dx.doi.org/10.1016/j.medntd.2023.100223
Xu, X., Ren, H., Chen, S., Luo, X., Zhao, F., & Xiong, Y. (2023). Review on melt flow simulations for thermoplastics and their fiber reinforced composites in fused deposition modeling. Journal of Manufacturing Processes, 92, 272-286.
https://doi.org/10.1016/j.jmapro.2023.02.039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62999
Vis, M., Zhao, F., Bodelier, E., Bood, C., Bulsink, J., Doeselaar, M., Amirabadi, H., Ito, K., & Hofmann, S. (2023). Osteogenesis and osteoclastogenesis on a chip: Engineering a self-assembling 3D coculture. Bone, 173, 116812
https://doi.org/10.1016/j.bone.2023.116812, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63546
http://dx.doi.org/10.1016/j.bone.2023.116812
Wildt, B., Zhao, F., Lauwers, I., Rietbergen, B., Ito, K., & Hofmann, S. (2023). Characterization of three‐dimensional bone‐like tissue growth and organization under influence of directional fluid flow. Biotechnology and Bioengineering, 120(7), 2013-2026.
https://doi.org/10.1002/bit.28418, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64828
http://dx.doi.org/10.1002/bit.28418
Bedding, M., Khatri, N., Nithiarasu, P., Sandnes, B., Egan, P., & Zhao, F. (2024). Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds. Journal of Engineering Design, 0, 1-15.
https://doi.org/10.1080/09544828.2024.2321224, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65980
Zauchner, D., Müller, M., Horrer, M., Bissig, L., Zhao, F., Fisch, P., Lee, S., Zenobi-Wong, M., Müller, R., & Qin, X. (2024). Synthetic biodegradable microporous hydrogels for in vitro 3D culture of functional human bone cell networks. Nature Communications, 15(1)
https://doi.org/10.1038/s41467-024-49280-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68087
http://dx.doi.org/10.1038/s41467-024-49280-3
Xu, X., Qiu, W., Wan, D., Wu, J., Zhao, F., & Xiong, Y. (2024). Numerical modelling of the viscoelastic polymer melt flow in material extrusion additive manufacturing. Virtual and Physical Prototyping, 19(1)
https://doi.org/10.1080/17452759.2023.2300666, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68088
http://dx.doi.org/10.1080/17452759.2023.2300666
Jovic, T., Zhao, F., Jia, H., Doak, S., & Whitaker, I. (2024). Orbital shaking conditions augment human nasoseptal cartilage formation in 3D culture. Frontiers in Bioengineering and Biotechnology, 12
https://doi.org/10.3389/fbioe.2024.1360089, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68089
http://dx.doi.org/10.3389/fbioe.2024.1360089

Holl Ymchwil

Erthyglau Cylchgronau

Xu, X., Qiu, W., Wan, D., Wu, J., Zhao, F., & Xiong, Y. (2024). Numerical modelling of the viscoelastic polymer melt flow in material extrusion additive manufacturing. Virtual and Physical Prototyping, 19(1)
https://doi.org/10.1080/17452759.2023.2300666, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68088
http://dx.doi.org/10.1080/17452759.2023.2300666
Zauchner, D., Müller, M., Horrer, M., Bissig, L., Zhao, F., Fisch, P., Lee, S., Zenobi-Wong, M., Müller, R., & Qin, X. (2024). Synthetic biodegradable microporous hydrogels for in vitro 3D culture of functional human bone cell networks. Nature Communications, 15(1)
https://doi.org/10.1038/s41467-024-49280-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68087
http://dx.doi.org/10.1038/s41467-024-49280-3
Bedding, M., Khatri, N., Nithiarasu, P., Sandnes, B., Egan, P., & Zhao, F. (2024). Data-driven calculation of porous geometry-dependent permeability and fluid-induced wall shear stress within tissue engineering scaffolds. Journal of Engineering Design, 0, 1-15.
https://doi.org/10.1080/09544828.2024.2321224, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65980
Jovic, T., Zhao, F., Jia, H., Doak, S., & Whitaker, I. (2024). Orbital shaking conditions augment human nasoseptal cartilage formation in 3D culture. Frontiers in Bioengineering and Biotechnology, 12
https://doi.org/10.3389/fbioe.2024.1360089, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa68089
http://dx.doi.org/10.3389/fbioe.2024.1360089
Vis, M., Zhao, F., Bodelier, E., Bood, C., Bulsink, J., Doeselaar, M., Amirabadi, H., Ito, K., & Hofmann, S. (2023). Osteogenesis and osteoclastogenesis on a chip: Engineering a self-assembling 3D coculture. Bone, 173, 116812
https://doi.org/10.1016/j.bone.2023.116812, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa63546
http://dx.doi.org/10.1016/j.bone.2023.116812
Wildt, B., Zhao, F., Lauwers, I., Rietbergen, B., Ito, K., & Hofmann, S. (2023). Characterization of three‐dimensional bone‐like tissue growth and organization under influence of directional fluid flow. Biotechnology and Bioengineering, 120(7), 2013-2026.
https://doi.org/10.1002/bit.28418, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64828
http://dx.doi.org/10.1002/bit.28418
Ahmed, H., Bedding-Tyrrell, M., Deganello, D., Xia, Z., Xiong, Y., & Zhao, F. (2023). Efficient calculation of fluid-induced wall shear stress within tissue engineering scaffolds by an empirical model. Medicine in Novel Technology and Devices, 18, 100223
https://doi.org/10.1016/j.medntd.2023.100223, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62890
http://dx.doi.org/10.1016/j.medntd.2023.100223
Xu, X., Ren, H., Chen, S., Luo, X., Zhao, F., & Xiong, Y. (2023). Review on melt flow simulations for thermoplastics and their fiber reinforced composites in fused deposition modeling. Journal of Manufacturing Processes, 92, 272-286.
https://doi.org/10.1016/j.jmapro.2023.02.039, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62999
Zhao, F., Xiong, Y., Ito, K., Rietbergen, B., & Hofmann, S. (2021). Porous Geometry Guided Micro-mechanical Environment Within Scaffolds for Cell Mechanobiology Study in Bone Tissue Engineering. Frontiers in Bioengineering and Biotechnology, 9, 736489
https://doi.org/10.3389/fbioe.2021.736489, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58151
Rubert, M., Vetsch, J., Lehtoviita, I., Sommer, M., Zhao, F., Studart, A., Müller, R., & Hofmann, S. (2021). Scaffold Pore Geometry Guides Gene Regulation and Bone-like Tissue Formation in Dynamic Cultures. Tissue Engineering Part A, 27(17-18), 1192-1204.
https://doi.org/10.1089/ten.tea.2020.0121, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa58125
Qi, L., Zhu, W., Qian, W., Xu, L., He, Y., & Zhao, F. (2021). The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments. Frontiers in Physiology, 12
https://doi.org/10.3389/fphys.2021.734565, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57927
Akiva, A., Melke, J., Ansari, S., Liv, N., Meijden, R., Erp, M., Zhao, F., Stout, M., Nijhuis, W., Heus, C., Ortera, C., Fermie, J., Klumperman, J., Ito, K., Sommerdijk, N., & Hofmann, S. (2021). An Organoid for Woven Bone. Advanced Functional Materials, 31(17), 2010524
https://doi.org/10.1002/adfm.202010524, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56465
http://dx.doi.org/10.1002/adfm.202010524
Zhao, F., Rietbergen, B., Ito, K., & Hofmann, S. (2020). Fluid flow‐induced cell stimulation in bone tissue engineering changes due to interstitial tissue formation in vitro. International Journal for Numerical Methods in Biomedical Engineering, 36(6)
https://doi.org/10.1002/cnm.3342, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55894
Zhao, F., Lacroix, D., Ito, K., Rietbergen, B., & Hofmann, S. (2020). Changes in scaffold porosity during bone tissue engineering in perfusion bioreactors considerably affect cellular mechanical stimulation for mineralization. Bone Reports, 12, 100265
https://doi.org/10.1016/j.bonr.2020.100265, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53924
Melke, J., Zhao, F., Ito, K., & Hofmann, S. (2020). Orbital seeding of mesenchymal stromal cells increases osteogenic differentiation and bone‐like tissue formation. Journal of Orthopaedic Research, 38(6), 1228-1237.
https://doi.org/10.1002/jor.24583, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55895
Driessen, R., Zhao, F., Hofmann, S., Bouten, C., Sahlgren, C., & Stassen, O. (2020). Computational Characterization of the Dish-In-A-Dish, A High Yield Culture Platform for Endothelial Shear Stress Studies on the Orbital Shaker. Micromachines, 11(6), 552
https://doi.org/10.3390/mi11060552, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54857
Kreutzer, J., Viehrig, M., Pölönen, R., Zhao, F., Ojala, M., Aalto-Setälä, K., & Kallio, P. (2019). Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes. Biomechanics and Modeling in Mechanobiology
https://doi.org/10.1007/s10237-019-01211-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51678
Qu, Y., Zhao, F., Wang, X., Liu, J., Li, J., Song, Z., & Wang, Z. (2019). Cardiomyocyte contractile force changes in response to AGRWE detected by AFM. Micro & Nano Letters, 14(5), 511-514.
https://doi.org/10.1049/mnl.2018.5458, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51680
Zhao, F., Melke, J., Ito, K., Rietbergen, B., & Hofmann, S. (2019). A multiscale computational fluid dynamics approach to simulate the micro-fluidic environment within a tissue engineering scaffold with highly irregular pore geometry. Biomechanics and Modeling in Mechanobiology, 18
https://doi.org/10.1007/s10237-019-01188-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51679
Zhao, F., Rietbergen, B., Ito, K., & Hofmann, S. (2018). Flow rates in perfusion bioreactors to maximise mineralisation in bone tissue engineering in vitro. Journal of Biomechanics, 79, 232-237.
https://doi.org/10.1016/j.jbiomech.2018.08.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51681
Melke, J., Zhao, F., Rietbergen, B., Ito, K., & Hofmann, S. (2018). Localisation of mineralised tissue in a complex spinner flask environment correlates with predicted wall shear stress level localisation. European Cells and Materials, 36, 57-68.
https://doi.org/10.22203/eCM.v036a05, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51682
http://www.ecmjournal.org/papers/vol036/vol036a05.php
Zhao, F., Garrigle, M., Vaughan, T., & McNamara, L. (2018). In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm. Biomechanics and Modeling in Mechanobiology, 17(1), 5-18.
https://doi.org/10.1007/s10237-017-0941-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51684
Qu, Y., Wang, Z., Zhao, F., Liu, J., Zhang, W., Li, J., Song, Z., & Xu, H. (2018). AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract. Micron, 104, 1-7.
https://doi.org/10.1016/j.micron.2017.10.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51683
Zhao, F., Vaughan, T., Mc Garrigle, M., & McNamara, L. (2017). A coupled diffusion-fluid pressure model to predict cell density distribution for cells encapsulated in a porous hydrogel scaffold under mechanical loading. Computers in Biology and Medicine, 89, 181-189.
https://doi.org/10.1016/j.compbiomed.2017.08.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51685
Virjula, S., Zhao, F., Leivo, J., Vanhatupa, S., Kreutzer, J., Vaughan, T., Honkala, A., Viehrig, M., Mullen, C., Kallio, P., McNamara, L., & Miettinen, S. (2017). The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells. Journal of the Mechanical Behavior of Biomedical Materials, 72, 38-48.
https://doi.org/10.1016/j.jmbbm.2017.04.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51687
Zhao, F., Vaughan, T., & McNamara, L. (2015). Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures. Biomechanics and Modeling in Mechanobiology, 15(3), 561-577.
https://doi.org/10.1007/s10237-015-0710-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51689
Zhao, F., Vaughan, T., & Mcnamara, L. (2015). Multiscale fluid–structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold. Biomechanics and Modeling in Mechanobiology, 14(2), 231-243.
https://doi.org/10.1007/s10237-014-0599-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51692
Zhao, F., Kreutzer, J., Pajunen, S., & Kallio, P. (2014). Mechanical Analysis of a Pneumatically Actuated Concentric Double-Shell Structure for Cell Stretching. Micromachines, 5(4), 868-885.
https://doi.org/10.3390/mi5040868, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51690
Hu, K., Zhao, F., & Wang, Q. (2013). Mechanical characterization of living and dead undifferentiated human adipose-derived stem cells by using atomic force microscopy. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 227(12), 1319-1323.
https://doi.org/10.1177/0954411913503064, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51693

Cyfraniadau Cynadleddau

Qian, W., Qi, L., Xu, L., He, Y., Zhao, F., & Sun, Y. (2017). Finite element analysis of a new type of post dilatation ballon catheter in PCI. In 5th international conference on Computational and Mathematical Biomedical Engineering, CMBE 20175th International Conference on Computational & Mathematical Biomedical Engineering (CMBE2017).
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51686
Zhao, F., Kreutzer, J., & Kallio, P. (2014). Computational modeling and structural improvement of a pneumatically actuated concentric double-shell structure for cell stretching.
https://doi.org/10.1109/ICMA.2014.6885818, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51691

Cynnyrch Ymchwil Arall

Zhao, F. (2016). In silico bone tissue engineering-a multiscale and multiphysics approach
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51688
Zhao, F. (2012). Modelling of Three Dimensional Elastomer Structures for Cell Stimulation Using Finite Element Method
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51694

Goruchwyliaeth

Image analysis and improved graphic design of a 3D-printed bone graft substitute (cyfredol)

PhD

Goruchwyliwr arall: Prof Davide Deganello
Electroelastic Vibration of Microtubules as Nanobiosensors for Early Diagnosis of Cancer (cyfredol)

PhD

Goruchwyliwr arall: Dr Chengyuan Wang
An in silico framework for tissue engineering scaffold design and characterisation (cyfredol)

PhD

Goruchwyliwr arall: Dr Bjornar Sandnes
THE FORMULATION OF RECOMBINANT COLLAGEN MATERIALS AS COATINGS IN MEDICAL DEVICES (cyfredol)

EngD

Goruchwyliwr arall: Dr Hari Arora
A Computational Approach to Bio-Ink Composition and Optimisation. (cyfredol)

MSc

Goruchwyliwr arall: Dr Christopher Wright

Modiwlau a Addysgir

EG-236 Design for Medical Engineering

This module has two main components: Component 1 (Engineering drawing and CAD): The first is the development of their engineering drawing skills using a CAD software package to the required British Standard. Component 2 (Design project): The second component involves the students working together in groups to address a 'real-world' medical device design brief. Students will be introduced to the medical design development process, which they will follow in order to develop their product concepts. There will be an emphasis on the importance of identifying end user needs (i.e. functional requirements), and how these inform the design process. The importance of having a robust product design specification is emphasised, along with an introduction to innovative design tools and approaches. The selected concept design will be developed virtually in CAD. Each group participant will be responsible for a component or element of the device, which will then be part of the overall product assembly which will be outlined in the group element of the report.
EG-M328 Implant and prosthetic Technology

This module looks at medical devices implanted within the human body and prosthetics, from two perspectives; i) how to engineer devices/implants to best deliver the required biological function and ii) the impact of implants on the human body.
EGA163 Design and Laboratory Classes 1

This module is split into two parts. Firstly, Competence in engineering drawing using CAD. Secondly essential laboratory skills, including mechanical testing, microscopy (light, electron, X-ray), virtual reality to explore microstructures, and laboratory report writing and lab book keeping.
EGA308 Implant and prosthetic Technology

This module looks at medical devices implanted within the human body and prosthetics, from two perspectives; i) how to engineer devices/implants to best deliver the required biological function and ii) the impact of implants on the human body.
EGIM02 Advanced Computational Methods for Engineers

Introduction to advanced computational (numerical) methods including ordinary and partial differential equations at masters level. The course provides an understanding of fundamental methods that form the basis of common solution techniques used in many simulators and commercial packages with wide application in science and engineering.
EGM403 Implant Engineering 2

This module is an advanced look at the design, fabrication and optimisation of medical implants and prosthetics. Case studies will be used to bring together engineering concepts and apply them to key devices that are used to treat disease and assist patients.

Dr Feihu Zhao

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Cyfraniadau Cynadleddau

Cynnyrch Ymchwil Arall

Goruchwyliaeth

Image analysis and improved graphic design of a 3D-printed bone graft substitute (cyfredol)

Electroelastic Vibration of Microtubules as Nanobiosensors for Early Diagnosis of Cancer (cyfredol)

An in silico framework for tissue engineering scaffold design and characterisation (cyfredol)

THE FORMULATION OF RECOMBINANT COLLAGEN MATERIALS AS COATINGS IN MEDICAL DEVICES (cyfredol)

A Computational Approach to Bio-Ink Composition and Optimisation. (cyfredol)

Modiwlau a Addysgir

EG-236 Design for Medical Engineering

EG-M328 Implant and prosthetic Technology

EGA163 Design and Laboratory Classes 1

EGA308 Implant and prosthetic Technology

EGIM02 Advanced Computational Methods for Engineers

EGM403 Implant Engineering 2