Dr Jonathan Mullins

Athro Cyswllt

Biomedical Sciences

j.g.l.mullins@abertawe.ac.uk

Siaradwr Cymraeg Rhugl

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0003-0144-2962

Trosolwg

Mae Jonathan yn arbenigwr ym maes cyfrifo strwythur, gweithrediad a rhyngweithiadau proteinau (derbynyddion, cludyddion, ensymau etc.) ar raddfa genom/proteom cyfan, a chysylltu hyn ag iechyd ac afiechyd a darganfod cyffuriau. Mae'n arwain grŵp ymchwil a chwmni deillio yn Ysgol Feddygaeth Prifysgol Abertawe, gan weithio ar ymchwil academaidd ac ymchwil a datblygu masnachol arloesol ym maes biowybodeg strwythurol. Nod y prosiectau hyn yw datrys amrywiaeth eang o broblemau biolegol, gan gynnwys prosiect cyfredol a ariennir gan Innovate UK â'r nod o ddatblygu platfform sgrinio cyffuriau gwrthfeirysol ar gyfer Covid-19. Mae'r ymchwil yn achub y blaen ar y feirws drwy fodelu amrywiolion a newidiadau strwythurol damcaniaethol, gan dargedu straeniau newydd cyn iddynt ddigwydd.

Meysydd Arbenigedd

• Biowybodeg Strwythurol
• Deallusrwydd Artiffisia
• Uwchgyfrifiadura
• Darganfod Cyffuriau
• Datblygu Platfformau
• Ymchwil Data Iechyd
• Covid-19

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae Jonathan yn darlithio ar y cwrs Meddygaeth i Raddedigion (biocemeg, metaboledd, geneteg, ffisioleg a phatholeg foleciwlaidd - yn enwedig mewn perthynas â'r coluddyn, ac mae'n arwain y thema Maeth). Mae hefyd yn addysgu ar y rhaglen Cydymaith Meddygol (endocrinoleg), y cwrs BSc mewn Geneteg/Biocemeg (biowybodeg) a'r BSc mewn Gwyddorau Meddygol Cymhwysol (niwroendocrinoleg) ac mae'n goruchwylio prosiectau’r drydedd flwyddyn ar gyfer y cyrsiau hynny.

Ymchwil Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Tan, W., Tan, A., Sivanandam, P., Goh, E., Yap, Z., Saburulla, N., Austin-Muttitt, K., Mullins, J., & Lau, A. (2020). In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate. Journal of Pharmacology and Experimental Therapeutics, 374(2), 295-307.
https://doi.org/10.1124/jpet.120.265249, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55640
Tucker, M., Lopez‐Ruiz, F., Cools, H., Mullins, J., Jayasena, K., & Oliver, R. (2020). Analysis of mutations in West Australian populations of Blumeria graminis f. sp. hordei CYP51 conferring resistance to DMI fungicides. Pest Management Science, 76(4), 1265-1272.
https://doi.org/10.1002/ps.5636, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53013
Chen, S., Austin-Muttitt, K., Zhang, L., Mullins, J., & Lau, A. (2019). In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues. Journal of Pharmacology and Experimental Therapeutics, 371(1), 75-86.
https://doi.org/10.1124/jpet.119.259267, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51722
Gardner, J., Cushion, T., Niotakis, G., Olson, H., Grant, P., Scott, R., Stoodley, N., Cohen, J., Naidu, S., Attie-Bitach, T., Bonnières, M., Boutaud, L., Encha-Razavi, F., Palmer-Smith, S., Mugalaasi, H., Mullins, J., Pilz, D., & Fry, A. (2018). Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation. Brain Sciences, 8(8), 145
https://doi.org/10.3390/brainsci8080145, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43598
Mullins, J., Fry, A., Fawcett, K., Zelnik, N., Yuan, H., Thompson, B., Shemer-Meiri, L., Cushion, T., Mugalaasi, H., Sims, D., Stoodley, N., Chung, S., Rees, M., Patel, C., Brueton, L., Layet, V., Giuliano, F., Kerr, M., Banne, E...., & Pilz, D. (2018). De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain, 141(3), 698-712.
https://doi.org/10.1093/brain/awx358, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38246

Holl Ymchwil

Erthyglau Cylchgronau

Stark, R., Dempsey, H., Kleeman, E., Sassi, M., Osborne-Lawrence, S., Sheybani-Deloui, S., Rushby, H., Mirth, C., Austin-Muttitt, K., Mullins, J., Zigman, J., Davies, J., & Andrews, Z. (2024). Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism. Molecular Metabolism, 89, 102025
https://doi.org/10.1016/j.molmet.2024.102025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa67734
Al-Amri, A., Armstrong, P., Amici, M., Ligneul, C., Rouse, J., El-Asrag, M., Pantiru, A., Vancollie, V., Ng, H., Ogbeta, J., Goodchild, K., Ellegood, J., Lelliott, C., Mullins, J., Bretman, A., Al-Ali, R., Beetz, C., Al-Gazali, L., Shamsi, A...., & Clapcote, S. (2022). PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies. Biological Psychiatry, 92(4), 323-334.
https://doi.org/10.1016/j.biopsych.2021.12.017, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59175
Lamb, D., Goldstone, J., Zhao, B., Lei, L., Mullins, J., Allen, M., Kelly, S., & Stegeman, J. (2022). Characterization of a Virally Encoded Flavodoxin That Can Drive Bacterial Cytochrome P450 Monooxygenase Activity. Biomolecules, 12(8), 1107
https://doi.org/10.3390/biom12081107, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa62081
Pospiech, M., Owens, S., Miller, D., Austin-Muttitt, K., Mullins, J., Cronin, J., Allemann, R., & Sheldon, M. (2021). Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol‐dependent cytolysins. The FASEB Journal, 35(6), 1-19.
https://doi.org/10.1096/fj.202100164r, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56884
Abdel-Khalik, J., Hearn, T., Dickson, A., Crick, P., Yutuc, E., Austin-Muttitt, K., Bigger, B., Morris, A., Shackleton, C., Clayton, P., Iida, T., Sircar, R., Rohatgi, R., Marschall, H., Sjövall, J., Björkhem, I., Mullins, J., Griffiths, W., & Wang, Y. (2021). Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates. The Journal of Steroid Biochemistry and Molecular Biology, 206, 105794
https://doi.org/10.1016/j.jsbmb.2020.105794, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55690
Tan, W., Tan, A., Sivanandam, P., Goh, E., Yap, Z., Saburulla, N., Austin-Muttitt, K., Mullins, J., & Lau, A. (2020). In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate. Journal of Pharmacology and Experimental Therapeutics, 374(2), 295-307.
https://doi.org/10.1124/jpet.120.265249, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55640
Tucker, M., Lopez‐Ruiz, F., Cools, H., Mullins, J., Jayasena, K., & Oliver, R. (2020). Analysis of mutations in West Australian populations of Blumeria graminis f. sp. hordei CYP51 conferring resistance to DMI fungicides. Pest Management Science, 76(4), 1265-1272.
https://doi.org/10.1002/ps.5636, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53013
Chen, S., Austin-Muttitt, K., Zhang, L., Mullins, J., & Lau, A. (2019). In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues. Journal of Pharmacology and Experimental Therapeutics, 371(1), 75-86.
https://doi.org/10.1124/jpet.119.259267, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa51722
Gardner, J., Cushion, T., Niotakis, G., Olson, H., Grant, P., Scott, R., Stoodley, N., Cohen, J., Naidu, S., Attie-Bitach, T., Bonnières, M., Boutaud, L., Encha-Razavi, F., Palmer-Smith, S., Mugalaasi, H., Mullins, J., Pilz, D., & Fry, A. (2018). Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation. Brain Sciences, 8(8), 145
https://doi.org/10.3390/brainsci8080145, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa43598
Mullins, J., Fry, A., Fawcett, K., Zelnik, N., Yuan, H., Thompson, B., Shemer-Meiri, L., Cushion, T., Mugalaasi, H., Sims, D., Stoodley, N., Chung, S., Rees, M., Patel, C., Brueton, L., Layet, V., Giuliano, F., Kerr, M., Banne, E...., & Pilz, D. (2018). De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain, 141(3), 698-712.
https://doi.org/10.1093/brain/awx358, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa38246
Skibinski, D., Ghiselli, F., Diz, A., Milani, L., & Mullins, J. (2017). Structure-Related Differences between Cytochrome Oxidase I Proteins in a Stable Heteroplasmic Mitochondrial System. Genome Biology and Evolution, 9(12), 3265-3281.
https://doi.org/10.1093/gbe/evx235, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37121
Mair, W., Deng, W., Mullins, J., West, S., Wang, P., Besharat, N., Ellwood, S., Oliver, R., Lopez-Ruiz, F., & Mullins, J. (2016). Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51. Frontiers in Microbiology, 7
https://doi.org/10.3389/fmicb.2016.01279, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30276
Chen, X., Zhang, B., Xiao, J., Ju, F., Li, S., Ren, C., An, L., Chen, T., Liu, G., Facey, P., Mullins, J., & Dyson, P. (2015). RfiA, a novel PAP2 domain-containing polytopic membrane protein that confers resistance to the FtsZ inhibitor PC190723. Future Microbiology, 10(3), 325-335.
https://doi.org/10.2217/fmb.14.131, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20615
http://www.futuremedicine.com/doi/abs/10.2217/fmb.14.131?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dwww.ncbi.nlm.nih.gov
Oegema, R., Cushion, T., Phelps, I., Chung, S., Dempsey, J., Collins, S., Mullins, J., Dudding, T., Gill, H., Green, A., Dobyns, W., Ishak, G., Rees, M., & Doherty, D. (2015). Recognisable cerebellar dysplasia associated with mutations in multiple tubulin genes. Human Molecular Genetics, ddv250
https://doi.org/10.1093/hmg/ddv250, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa22310
McGirr, A., Lipina, T., Mun, H., Georgiou, J., Al-Amri, A., Ng, E., Zhai, D., Elliott, C., Cameron, R., Mullins, J., Liu, F., Baillie, G., Clapcote, S., Roder, J., & Mullins, J. (2015). Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition. Neuropsychopharmacology, 41(4), 1080-1092.
https://doi.org/10.1038/npp.2015.240, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30275
http://europepmc.org/abstract/med/26272049
Price, C., Warrilow, A., Parker, J., Mullins, J., Nes, W., Kelly, D., Kelly, S., & Schottel, J. (2015). Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. Applied and Environmental Microbiology, 81(10), 3379-3386.
https://doi.org/10.1128/AEM.03965-14, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20704
Johnston, A., Kang, J., Shen, W., Pickrell, W., Cushion, T., Davies, J., Baer, K., Mullins, J., Hammond, C., Chung, S., Thomas, R., White, C., Smith, P., Macdonald, R., Rees, M., & Pickrell, O. (2014). A Novel GABRG2 mutation, p.R136*, in a family with GEFS+ and extended phenotypes. Neurobiology of Disease
https://doi.org/10.1016/j.nbd.2013.12.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17001
Cushion, T., Paciorkowski, A., Pilz, D., Mullins, J., Seltzer, L., Marion, R., Tuttle, E., Ghoneim, D., Christian, S., Chung, S., Rees, M., Dobyns, W., Mullins, J., & Rees, M. (2014). De Novo Mutations in the Beta-Tubulin Gene TUBB2A Cause Simplified Gyral Patterning and Infantile-Onset Epilepsy. The American Journal of Human Genetics, 94(4), 634-641.
https://doi.org/10.1016/j.ajhg.2014.03.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17821
Parker, J., Warrilow, A., Price, C., Mullins, J., Kelly, D., & Kelly, S. (2014). Resistance to antifungals that target CYP51. Journal of Chemical Biology, 7(4), 143-161.
https://doi.org/10.1007/s12154-014-0121-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18694
Chung, S., Bode, A., Cushion, T., Thomas, R., Hunt, C., Wood, S., Pickrell, W., Drew, C., Yamashita, S., Shiang, R., Leiz, S., Longhardt, A., Raile, V., Weschke, B., Puri, R., Verma, I., Harvey, R., Ratnasinghe, D., Parker, M...., & Pickrell, O. (2013). GLRB is the third major gene of effect in hyperekplexia. Human Molecular Genetics, 22(5), 927-940.
https://doi.org/10.1093/hmg/dds498, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13840
Cushion, T., Dobyns, W., Mullins, J., Stoodley, N., Chung, S., Fry, A., Hehr, U., Gunny, R., Aylsworth, A., Prabhakar, P., Uyanik, G., Rankin, J., Rees, M., Pilz, D., Mullins, J., Rees, M., Chung, S., & Cushion, T. (2013). Overlapping cortical malformations and mutations in TUBB2B and TUBA1A. BRAIN, 136(2), 536-548.
https://doi.org/10.1093/brain/aws338, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14338
Thomas, R., Chung, S., Wood, S., Cushion, T., Drew, C., Hammond, C., Vanbellinghen, J., Mullins, J., Rees, M., Mullins, J., Rees, M., Chung, S., & Thomas, R. (2013). Genotype-phenotype correlations in hyperekplexia: apnoeas, learning difficulties and speech delay. Brain
https://doi.org/10.1093/brain/awt207, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16195
Chung, S., Bode, A., Cushion, T., Thomas, R., Hunt, C., Wood, S., Pickrell, W., Drew, C., Yamashita, S., Shiang, R., Leiz, S., Longhardt, A., Raile, V., Weschke, B., Puri, R., Verma, I., Harvey, R., Ratnasinghe, D., Parker, M...., & Mullins, J. (2013). GLRB is the third major gene of effect in hyperekplexia. Human Molecular Genetics, 22(5), 927-940.
https://doi.org/10.1093/hmg/dds498, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14243
Davis, C., Harris, H., Hu, K., Drummer, H., McKeating, J., Mullins, J., & Balfe, P. (2012). In silicodirected mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface. Cellular Microbiology, 14(12), 1892-1903.
https://doi.org/10.1111/cmi.12008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13029
Warrilow, A., Mullins, J., Hull, C., Parker, J., Lamb, D., Kelly, D., Kelly, S., & Mullins, J. (2012). S279 Point Mutations in Candida albicans Sterol 14- Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole. Antimicrobial Agents and Chemotherapy, 56(4), 2099-2107.
https://doi.org/10.1128/AAC.05389-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14242
Moody, S., Zhao, B., Lei, L., Mullins, J., Waterman, M., Kelly, S., & Lamb, D. (2012). Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.. FEBS J., 279(9), 1640-1649.
https://doi.org/10.1111/j.1742-4658.2011.08447.x., SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10672
Mullins, J., Parker, J., Cools, H., Togawa, R., Lucas, J., Fraaije, B., Kelly, D., & Kelly, S. (2011). Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola. PLoS ONE, 6(6), e20973
https://doi.org/10.1371/journal.pone.0020973, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6839
Cools, H., Mullins, J., Fraaije, B., Parker, J., Kelly, D., Lucas, J., & Kelly, S. (2011). Impact of Recently Emerged Sterol 14 alpha-Demethylase (CYP51) Variants of Mycosphaerella graminicola on Azole Fungicide Sensitivity. Applied and Environmental Microbiology, 77(11), 3830-3837.
https://doi.org/10.1128/AEM.00027-11, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6846
Martel, C., Warrilow, A., Jackson, C., Mullins, J., Togawa, R., Parker, J., Morris, M., Donnison, I., Kelly, D., Kelly, S., Mullins, J., & Hull, C. (2010). Expression, purification and use of the soluble domain of Lactobacillus paracasei β-fructosidase to optimise production of bioethanol from grass fructans. Bioresource Technology, 101(12), 4395-4402.
https://doi.org/10.1016/j.biortech.2010.01.084, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6359
Bowen, A., Gonzalez, D., Mullins, J., Bhatt, A., Martinez, A., Conlan, R., & Conlan, S. (2010). PAH-Domain-Specific Interactions of the Arabidopsis Transcription Coregulator SIN3-LIKE1 (SNL1) with Telomere-Binding Protein 1 and ALWAYS EARLY2 Myb-DNA Binding Factors. Journal of Molecular Biology, 395(5), 937-949.
https://doi.org/10.1016/j.jmb.2009.11.065, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10489
Chung, S., Vanbellingham, J., Mullins, J., & Mullins, J. (2010). Pathophysiological basis of novel GLRA1 mutations in human hyperekplexia.. J. Neurosci., 30, 9612-9620.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9936
Harris, H., Davis, C., Mullins, J., Hu, K., Goodall, M., Farquhar, M., Mee, C., McCaffrey, K., Young, S., Drummer, H., Balfe, P., McKeating, J., & Mullins, J. (2010). Claudin Association with CD81 Defines Hepatitis C Virus Entry. Journal of Biological Chemistry, 285(27), 21092-21102.
https://doi.org/10.1074/jbc.M110.104836, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9937
Chung, S., Vanbellinghen, J., Mullins, J., Robinson, A., Hantke, J., Hammond, C., Gilbert, D., Freilinger, M., Ryan, M., Kruer, M., Masri, A., Gurses, C., Ferrie, C., Harvey, K., Shiang, R., Christodoulou, J., Andermann, F., Andermann, E., Thomas, R...., & Chung, S. (2010). Pathophysiological Mechanisms of Dominant and Recessive GLRA1 Mutations in Hyperekplexia. Journal of Neuroscience, 30(28), 9612-9620.
https://doi.org/10.1523/JNEUROSCI.1763-10.2010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9949
Davies, J., Chung, S., Thomas, R., Robinson, A., Hammond, C., Mullins, J., Carta, E., Pearce, B., Harvey, K., Harvey, R., Rees, M., & Davies, J. (2010). The glycinergic system in human startle disease: a genetic screening approach. Frontiers in Molecular Neuroscience, 3, 8-16.
https://doi.org/10.3389/fnmol.2010.00008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13967
Lamb, D., Lei, L., Warrilow, A., Lepesheva, G., Mullins, J., Waterman, M., Kelly, S., & Mullins, J. (2009). The First Virally Encoded Cytochrome P450. Journal of Virology, 83(16), 8266-8269.
https://doi.org/10.1128/JVI.00289-09, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa6352
Kelly, D., Kraševec, N., Mullins, J., & Nelson, D. (2009). The CYPome (Cytochrome P450 complement) of Aspergillus nidulans. Fungal Genetics and Biology, 46(1), S53-S61.
https://doi.org/10.1016/j.fgb.2008.08.010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10172
Wortman, J., Gilsenan, J., Joardar, V., Deegan, J., Clutterbuck, J., Andersen, M., Archer, D., Bencina, M., Braus, G., Coutinho, P., & Mullins, J. (2009). The 2008 update of the Aspergillus nidulans genome annotation: A community effort. Fungal Genetics and Biology, 46(1), S2-S13.
https://doi.org/10.1016/j.fgb.2008.12.003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa16275
Kelly, D., Kra?evec, N., Mullins, J., & Mullins, J. (2009). The CYPome (Cytochrome P450 complement) of Aspergillus nidulans.. Fungal Genetics and Biology, 46, S53-61.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9939
Yang, T., Chung, S., Zhang, W., Mullins, J., McCulley, C., Crawford, J., MacCormick, J., Eddy, C., Shelling, A., French, J., Yang, P., Skinner, J., Roden, D., Rees, M., Mullins, J., Rees, M., & Chung, S. (2009). Biophysical Properties of 9 KCNQ1 Mutations Associated With Long-QT Syndrome. Circulation: Arrhythmia and Electrophysiology, 2(4), 417-426.
https://doi.org/10.1161/CIRCEP.109.850149, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10138
Lasso, G., Antoniw, J., Mullins, J., & Mullins, J. (2006). A combinatorial pattern discovery approach for the prediction of membrane dipping (re-entrant) loops. Bioinformatics, 22(14), e290-e297.
https://doi.org/10.1093/bioinformatics/btl209, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1431
Sol, R., Mullins, J., Grantcharova, N., Flardh, K., Dyson, P., Dyson, P., Del Sol Abascal, R., & Mullins, J. (2006). Influence of CrgA on Assembly of the Cell Division Protein FtsZ during Development of Streptomyces coelicolor. Journal of Bacteriology, 188(4), 1540
https://doi.org/10.1128/JB.188.4.1540-1550.2006, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1418
Hedfalk, K. & Mullins, J. (2004). A Regulatory Domain in the C-terminal Extension of the Yeast Glycerol Channel Fps1p. Journal of Biological Chemistry, 279(15), 14954-14960.
https://doi.org/10.1074/jbc.M313126200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1428
Althage, M., Bizouarn, T., Kindlund, B., Mullins, J., Alander, J., Rydström, J., & Mullins, J. (2004). Cross-linking of transmembrane helices in proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli: implications for the structure and function of the membrane domain..
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30284
http://europepmc.org/abstract/med/15511529
Karlgren, S., Filipsson, C., Mullins, J., Bill, R., Tamás, M., Hohmann, S., & Mullins, J. (2004). Identification of residues controlling transport through the yeast aquaglyceroporin Fps1 using a genetic screen. European Journal of Biochemistry, 271(4), 771-779.
https://doi.org/10.1111/j.1432-1033.2004.03980.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30285
http://europepmc.org/abstract/med/14764093
Tamas, M. & Mullins, J. (2003). A Short Regulatory Domain Restricts Glycerol Transport through Yeast Fps1p. Journal of Biological Chemistry, 278(8), 6337-6345.
https://doi.org/10.1074/jbc.M209792200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1429
Togawa, R., Antoniw, J., Mullins, J., & Mullins, J. (2001). TMCompare: transmembrane region sequence and structure. Bioinformatics, 17(12), 1238-1239.
https://doi.org/10.1093/bioinformatics/17.12.1238, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30286
http://europepmc.org/abstract/med/11751238
Adams, M., Antoniw, J., Mullins, J., & Mullins, J. (2001). Plant virus transmission by plasmodiophorid fungi is associated with distinctive transmembrane regions of virus-encoded proteins. Archives of Virology, 146(6), 1139-1153.
https://doi.org/10.1007/s007050170111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30287
http://europepmc.org/abstract/med/11504421
Bill, R. & Mullins, J. (2001). Analysis of the Pore of the Unusual Major Intrinsic Protein Channel, Yeast Fps1p. Journal of Biological Chemistry, 276(39), 36543-36549.
https://doi.org/10.1074/jbc.M105045200, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1430
Punchard, N., Cason, J., Mullins, J., Chander, C., Thompson, R., & Mullins, J. (2000). Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis. Mediators of Inflammation, 9(3-4), 189-191.
https://doi.org/10.1080/09629350020002903, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30290
http://europepmc.org/abstract/med/11132777
Thomas, G., Mullins, J., Merrick, M., & Mullins, J. (2000). Membrane topology of the Mep/Amt family of ammonium transporters. Molecular Microbiology, 37(2), 331-344.
https://doi.org/10.1046/j.1365-2958.2000.01994.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30288
http://europepmc.org/abstract/med/10931328
Punchard, N., Green, A., Mullins, J., Thompson, R., & Mullins, J. (2000). Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 62(1), 27-33.
https://doi.org/10.1054/plef.1999.0121, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30289
http://europepmc.org/abstract/med/10765976
Diao, A., Chen, J., Gitton, F., Antoniw, J., Mullins, J., Hall, A., Adams, M., & Mullins, J. (1999). Sequences of European Wheat Mosaic Virus and Oat Golden Stripe Virus and Genome Analysis of the Genus Furovirus. Virology, 261(2), 331-339.
https://doi.org/10.1006/viro.1999.9880, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30291
http://europepmc.org/abstract/med/10497118
Mullins, J., Green, A., Thompson, R., Punchard, N., & Mullins, J. (1998). Effect of the bile acid: fatty acid ratio onin vivoessential fatty acid absorption in the rat. Biochemical Society Transactions, 26(2), S178-S178.
https://doi.org/10.1042/bst026s178, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30292
http://europepmc.org/abstract/med/9649853
Mullins, J., Knight, G., Gilani, S., Murphy, G., Wilkinson, M., & Mullins, J. (1998). Functional expression of Na+-independent bile acid transport inXenopus laevisoocytes following injection with pig intestinal mRNA. Biochemical Society Transactions, 26(2), S179-S179.
https://doi.org/10.1042/bst026s179, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30293
http://europepmc.org/abstract/med/9649854
Mullins, J., Antoniw, J., Gilani, S., Murphy, G., Wilkinson, M., & Mullins, J. (1998). Molecular modelling of the mechanism of bile acid transport by the hepatocyte canalicular ecto-ATPase (CAM-105). Biochemical Society Transactions, 26(2), S123-S123.
https://doi.org/10.1042/bst026s123, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30294
http://europepmc.org/abstract/med/9649798
Mullins, J., Beechey, R., Gould, G., Campbell, F., Shirazi-Beechey, S., & Mullins, J. (1992). Characterization of the ileal Na+/bile salt co-transporter in brush border membrane vesicles and functional expression inXenopus laevisoocytes. Biochemical Journal, 285(3), 785-790.
https://doi.org/10.1042/bj2850785, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30295
http://europepmc.org/abstract/med/1497617
Campbell, F., Smith, D., Waldron, B., Tait, I., Shirazi-Beechey, S., Mullins, J., Hopwood, D., & Mullins, J. (1991). Mucosal function after ileal mucosal fenestration and colonic autotransplantation. British Journal of Surgery, 78(11), 1309-1312.
https://doi.org/10.1002/bjs.1800781111, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa30296
http://europepmc.org/abstract/med/1760689

Penodau Llyfrau

Mullins, J. (2012). Structural Modelling Pipelines in Next Generation Sequencing Projects. Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research (pp. 117-167).
https://doi.org/10.1016/B978-0-12-394287-6.00005-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14241
Mullins, J., Chung, S., Rees, M., & Mullins, J. (2010). Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling. Advances in Protein Chemistry and Structural Biology (pp. 117-152).
https://doi.org/10.1016/B978-0-12-381264-3.00004-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13964

Goruchwyliaeth

Computational Structure, Function and Binding Analysis of Proteins in the Human Kidney (cyfredol)

PhD

Goruchwyliwr arall: Dr Salvatore Ferla
Natural language processing (NLP) for clinical information extraction and healthcare research (dyfarnwyd 2023)

PhD

Goruchwyliwr arall: Prof Julian Halcox
Development and application of a novel mass spectrometry ionisation source for biological chemistry (dyfarnwyd 2022)

PhD

Goruchwyliwr arall: Prof Steven Kelly
Bioinformatics investigation of the amyloid precursor protein and its interactions with presenilin-1 and acetylcholinesterase in early onset familial Alzheimer's disease (cyfredol)

MSc

Goruchwyliwr arall: Dr Alwena Morgan
Generative AI in Protein Design: De novo Protein Design and Multi-Motif Scaffolding (cyfredol)

MSc

Goruchwyliwr arall: Dr Yuanbo Wu
Development of a combined database / in silico pipeline for the investigation of novel approaches for precision medicine (dyfarnwyd 2023)

MSc

Goruchwyliwr arall: Dr Salvatore Ferla
An investigation of the complex relationships between different neurological disorders and their associated pathways, using genome-scale bioinformatics platforms. (cyfredol)

MSc

Goruchwyliwr arall: Dr Jeffrey Davies

Modiwlau a Addysgir

PM-239F Doctor as Scholar and Scientist 1

This module provides medical students with the foundation of scientific knowledge, which is required for the practice of medicine. Based on the professional knowledge domain of the GMC¿s ¿Outcomes for Graduates (2020), this module enables students to develop their scientific knowledge within a clinical context.
PM-240F Doctor as a Practitioner 1

This module provides medical students with the foundation clinical skills required for the practice of medicine. Based on the professional skills domain of the GMC¿s Outcomes for Graduates (2020), and Outcomes for Graduates ¿ Practical Skills and Procedures (2020), this module enables students to develop their skills within a safe but clinically-focused environment.
PM-276 Neuroanatomy and neurology

Building on `An introduction to Neuroscience¿ this module will combine fundamental neuroscience with clinical neurology to provide a comprehensive understanding of the nervous system in health and disease.
PM-276C Niwroanatomeg a Niwroleg

Gan adeiladu ar 'Cyflwyniad i Niwrowyddoniaeth' bydd y modiwl hwn yn cyfuno niwrowyddoniaeth sylfaenol â niwroleg glinigol i ddarparu dealltwriaeth gynhwysfawr o'r system nerfol ym maes iechyd a chlefydau.
PM-344C Prosiect Capfaen

Nod y modiwl hwn yw rhoi cyfle i fyfyrwyr gael profiad dysgu capfaen drwy gymryd rhan yn eu prosiect eu hunain yn seiliedig ar gwestiwn ymchwil. Gall y prosiect fod mewn labordy neu heb fod yn labordy ond bydd bob amser yn cynnwys cwestiwn ymchwil sy'n deillio o'r llenyddiaeth, ac sy'n canolbwyntio ar bwnc perthnasol i wyddor feddygol. Bydd yn gofyn cwestiwn ymchwil newydd ac yn cynnwys dadansoddiad beirniadol o ganfyddiadau ymchwil. Bydd myfyrwyr yn mireinio eu sgiliau cyfathrebu llafar ac ysgrifenedig i lefel raddedig, drwy lunio cyflwyniad rhagarweiniol ar gefndir y prosiect, ynghyd â thraethawd estynedig a chyflwyniad llafar ar ganfyddiadau eu hymchwil.
PM-349D Doctor as Scholar and Scientist 2

This module further develops the student's scientific knowledge, building on the foundations laid in Year 1. Based on the professional knowledge domain of the GMC's "Outcomes for Graduates (2020)" this module enables students to enhance their scientific knowledge and understanding of its importance to clinical practice within a clinical context.
PM-361 Bioinformatics: From Sequence to Function

The ever increasing availability of genome sequences and protein structure data demands that molecular biologists are proficient at performing extensive data analyses to guide and support traditional laboratory-based research. This Module will provide the theoretical basis and practical training on computational tools currently used to assemble and interrogate genome sequences, infer gene and protein functions, and to examine protein structure data.
PM-361C Biowybodeg: O ddilyniant i swyddogaeth

Mae argaeledd cynyddol dilyniannau genom a data strwythur protein yn mynnu bod biolegwyr moleciwlaidd yn hyfedr wrth berfformio dadansoddiadau data helaeth i arwain a chefnogi ymchwil draddodiadol mewn labordy. Bydd y Modiwl hwn yn darparu sylfaen ddamcaniaethol a hyfforddiant ymarferol ar offer cyfrifiadol a ddefnyddir ar hyn o bryd i gydosod a holi dilyniannau genom, casglu swyddogaethau genynnau a phrotein, ac i archwilio data strwythur protein.
PMRM04 Dissertation (Research)

This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study.

Grantiau a Phrosiectau Allweddol

Generic Rapid Antiviral Screening Platform (GRASP) 2020

Innovate UK, with Gyda chwmni cyswllt, Moleculomics, £39,203
Off-target receptor screening – Proof of concept study Phases 1, 2 & 3 2015 - 2019

Unilever plc, with Gyda chwmni cyswllt, Moleculomics, Heb ei ddatgelu
Protein-noble gas interaction interface R&D 2017

Air Liquide, with Gyda chwmni cyswllt, Moleculomics, Heb ei ddatgelu
Cross-species comparative in silico platform (CRISP) 2017

NC3Rs CRACK IT Solutions, with Gyda chwmni cyswllt, Moleculomics, £50,000
Developing novel SMO inhibitors to target the hedgehog signalling pathway in cancer 2017

Dyfarniad Effaith Sêr Cymru , with Ymgeisydd ar y cyd â Dr Yuqin Wang, £50,000
A software tool for patient stratification by genetic variations in drug metabolism 2017 - 2018

Innovate UK, with Gyda chwmni cyswllt, Moleculomics, a staff ym Mwrdd Iechyd Prifysgol Bae Abertawe, £99,540
Inhibiting IL-17 production by blocking endogenous RORYT agonists for the treatment of autoimmune diseases 2016

Llywodraeth Cymru, with Ymgeisydd ar y cyd â Dr Yuqin Wang, £40,000
Linking off-target MIEs and AOPs by in silico benchmarking of the ToxCast database 2015

NC3Rs CRACK-IT Challenge 18 - Targeting Off-Targets, £78,877
An in silico platform for the structural characterisation of host-pathogen interactomes 2014 - 2015

Y Ganolfan Mentergarwch Amddiffyn, with Gyda chwmni cyswllt, Moleculomics, £78,600
Extracting Structural Information from Genome Sequences to Inform Therapeutic Choice 2014 - 2016

Y Labordy Gwyddoniaeth a Thechnoleg Amddiffyn, with Gyda chwmni cyswllt, Moleculomics, Hebe ei ddatgelu
Optimisation and improving computational efficiency of multi-genome protein structure and screening platform 2014 - 2015

Uwchgyfrifiadura Cymru, £42,000
GDA Inhibitors 2014 - 2015

Llywodraeth Gymru – A4B, with Ymgeisydd ar y cyd â Dr Jeff Davies, £17,892
A multi-genome in silico platform for identification and screening of antimicrobial targets 2013 - 2014

Y Ganolfan Mentergarwch Amddiffyn, with Gyda chwmni cyswllt, Moleculomics, £64,200
Novel thermolabile enzymes for the production of high value food chemicals 2013 - 2014

Y Bwrdd Strategaeth Technoleg, ymgeisydd ar y cyd â Biocatalysts Ltd, Y Bwrdd Strategaeth Technoleg, ymgeisydd ar y cyd â Biocatalysts Ltd
Molecular engineering and functional analysis of cytokine trap peptides for modulation of the asthma IL-13 signalling pathway (a novel therapeutic peptide for asthma) 2011 - 2014

Ysgoloriaeth Ymchwil PhD NISCHR , with Ysgoloriaeth Ymchwil PhD NISCHR , £64,000

Hanes Gyrfa

Athro Cysylltiol, Prifysgol Abertawe

2003 - Presennol

Swyddi Cysylltiedig

Sefydlwr a Phrif Swyddog Gweithredu, Moleculomics Ltd

2012 - Presennol

Dr Jonathan Mullins

Cyfeiriad ebost

Welsh language proficiency

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Uchafbwyntiau Ymchwil

Holl Ymchwil

Computational Structure, Function and Binding Analysis of Proteins in the Human Kidney (cyfredol)

Natural language processing (NLP) for clinical information extraction and healthcare research (dyfarnwyd 2023)

Development and application of a novel mass spectrometry ionisation source for biological chemistry (dyfarnwyd 2022)

Bioinformatics investigation of the amyloid precursor protein and its interactions with presenilin-1 and acetylcholinesterase in early onset familial Alzheimer's disease (cyfredol)

Generative AI in Protein Design: De novo Protein Design and Multi-Motif Scaffolding (cyfredol)

Development of a combined database / in silico pipeline for the investigation of novel approaches for precision medicine (dyfarnwyd 2023)

An investigation of the complex relationships between different neurological disorders and their associated pathways, using genome-scale bioinformatics platforms. (cyfredol)

PM-239F Doctor as Scholar and Scientist 1

PM-240F Doctor as a Practitioner 1

PM-276 Neuroanatomy and neurology

PM-276C Niwroanatomeg a Niwroleg

PM-344C Prosiect Capfaen

PM-349D Doctor as Scholar and Scientist 2

PM-361 Bioinformatics: From Sequence to Function

PM-361C Biowybodeg: O ddilyniant i swyddogaeth

PMRM04 Dissertation (Research)

Generic Rapid Antiviral Screening Platform (GRASP) 2020

Off-target receptor screening – Proof of concept study Phases 1, 2 & 3 2015 - 2019

Protein-noble gas interaction interface R&D 2017

Cross-species comparative in silico platform (CRISP) 2017

Developing novel SMO inhibitors to target the hedgehog signalling pathway in cancer 2017

A software tool for patient stratification by genetic variations in drug metabolism 2017 - 2018

Inhibiting IL-17 production by blocking endogenous RORYT agonists for the treatment of autoimmune diseases 2016

Linking off-target MIEs and AOPs by in silico benchmarking of the ToxCast database 2015

An in silico platform for the structural characterisation of host-pathogen interactomes 2014 - 2015

Extracting Structural Information from Genome Sequences to Inform Therapeutic Choice 2014 - 2016

Optimisation and improving computational efficiency of multi-genome protein structure and screening platform 2014 - 2015

GDA Inhibitors 2014 - 2015

A multi-genome in silico platform for identification and screening of antimicrobial targets 2013 - 2014

Novel thermolabile enzymes for the production of high value food chemicals 2013 - 2014

Molecular engineering and functional analysis of cytokine trap peptides for modulation of the asthma IL-13 signalling pathway (a novel therapeutic peptide for asthma) 2011 - 2014

Athro Cysylltiol, Prifysgol Abertawe

Sefydlwr a Phrif Swyddog Gweithredu, Moleculomics Ltd