Institute of Life Science 1 internal Atrium view up.jpg

Dr Ume-kulsoom Shah

Technegydd (Ymchwil Gwyddor Bywyd)

Faculty of Medicine Health and Life Science

u.shah@abertawe.ac.uk

Swyddfa Academaidd - 429
Pedwerydd Llawr - DNA/Genetics
Y Sefydliad Gwyddor Bywyd 1
Campws Singleton

Dolenni Ymchwil

https://orcid.org/0000-0002-0594-580X

ResearchGate

Trosolwg

Mae Ume-Kulsoom yn gweithio fel y technegydd ymchwil ar y pedwerydd llawr yn y grŵp Tocsicoleg In Vitro yn yr Ysgol Feddygaeth. Mae hi'n cynnal ac yn cadw'r labordy yn unol â safonau ymchwil. Goruchwyliodd hi fyfyrwyr prosiect BSc mewn prosiectau a oedd yn ymwneud â difrod i DNA. Mae hi'n hyfforddi ac yn cynorthwyo aelodau staff newydd ac ymwelwyr. Mae hi'n ymchwilydd brwd sy'n ceisio ychwanegu gwybodaeth am ffactorau sy'n dylanwadu ar garsinogenigrwydd a genowenwyndra cemegion gwahanol sydd yn yr amgylchedd ac a ddefnyddir mewn bwyd ac eitemau pob dydd.

Meysydd Arbenigedd

Profi genowenwyndra
Profi mwtaniadau
Microsgopeg gydffocal
Profion meintiol fel PCR a qPCR
Profion ansoddol, e.e. Blotio Gorllewinol
Delweddu cydffocal
Dadansoddi data

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Wedi rhoi cymorth mewn dosbarthiadau ymarferol ac wedi cysgodi Kate Chapman er mwyn dysgu sgiliau addysgu

Ymchwil

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.
https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804
Shah, U., Mallia, J., Singh, N., Chapman, K., Doak, S., & Jenkins, G. (2018). A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 825, 51-58.
https://doi.org/10.1016/j.mrgentox.2017.12.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37674
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.
https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186
Shah, U., Verma, J., Chapman, K., Wilde, E., Tonkin, J., Brown, R., Johnson, G., Doak, S., & Jenkins, G. (2020). Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models. Mutagenesis, 35(6), 445-452.
https://doi.org/10.1093/mutage/geaa029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55770
Dural, E., Shah, U., Pritchard, D., Chapman, K., Doak, S., Jenkins, G., & Jenkins, G. (2020). The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro. Mutagenesis, 35(6), 479-489.
https://doi.org/10.1093/mutage/geaa024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55854
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
Chapman, K., Shah, U., Fletcher, J., Johnson, G., Doak, S., & Jenkins, G. (2024). An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens. Mutagenesis, 39(2), 69-77.
https://doi.org/10.1093/mutage/geae004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65653

Holl Ymchwil

Erthyglau Cylchgronau

Chapman, K., Shah, U., Fletcher, J., Johnson, G., Doak, S., & Jenkins, G. (2024). An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens. Mutagenesis, 39(2), 69-77.
https://doi.org/10.1093/mutage/geae004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65653
Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.
https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186
Shah, U., Verma, J., Chapman, K., Wilde, E., Tonkin, J., Brown, R., Johnson, G., Doak, S., & Jenkins, G. (2020). Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models. Mutagenesis, 35(6), 445-452.
https://doi.org/10.1093/mutage/geaa029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55770
Dural, E., Shah, U., Pritchard, D., Chapman, K., Doak, S., Jenkins, G., & Jenkins, G. (2020). The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro. Mutagenesis, 35(6), 479-489.
https://doi.org/10.1093/mutage/geaa024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55854
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Shah, U., Mallia, J., Singh, N., Chapman, K., Doak, S., & Jenkins, G. (2018). A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 825, 51-58.
https://doi.org/10.1016/j.mrgentox.2017.12.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37674
Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.
https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804