Institute of Life Science 1 internal Atrium view up

Yr Athro Gareth Jenkins

Cadair Bersonol

Biomedical Sciences

+44 (0) 1792 602512

g.j.jenkins@abertawe.ac.uk

Swyddfa Academaidd - 405
Pedwerydd Llawr - DNA/Genetics
Y Sefydliad Gwyddor Bywyd 1
Campws Singleton

Ar gael ar gyfer Goruchwyliaeth Ôl-raddedig

Dolenni Ymchwil

https://orcid.org/0000-0002-5437-8389

ResearchGate

Trosolwg

Cyhoeddodd yr Athro Jenkins ei 100fed papur yn 2019 ac mae'n eiriolwr angerddol dros ymchwil canser. Mae ganddo ddiddordeb mawr mewn canser a charcinogenau ac mae'n datblygu dulliau seiliedig ar waed i wneud diagnosis o ganser yn gynharach.

Enillodd yr Athro Jenkins BSc gan Kings College London, MSc o Brifysgol Gorllewin Lloegr a PhD o Brifysgol Cymru.

Mae ymchwil yr Athro Jenkins yn canolbwyntio ar sut mae carcinogenau yn achosi canser a sut y gallwn wneud diagnosis o ganser yn gynharach.

Mae ganddo ddiddordeb hirsefydlog mewn profi carcinogenau am eiddo sy'n niweidiol i DNA; gweithio gyda Diwydiant, cyrff rheoleiddio a chydweithredwyr rhyngwladol.

Mae ei grŵp wedi canolbwyntio ar ddulliau in vitro (seiliedig ar gelloedd) i ddisodli profion anifeiliaid ar gyfer carcinogenau.

Mae ei ymchwil canser yn canolbwyntio ar ddiagnosis cynnar (canser yr oesoffagws) ac ar hyn o bryd mae'n asesu dulliau diagnostig mwtanol yn y gwaed i nodi cleifion canser risg uchel a mynd i'r afael â chwestiynau am ddatguddiadau i garsinogenau.

Meysydd Arbenigedd

Carcinogen
(Geno) Tocsicoleg
Niwed DNA
Profi In Vitro
Diagnosis Cynnar (Canser Oesophageal)
Diagnosteg Treigladau Gwaed

Uchafbwyntiau Gyrfa

Diddordebau Addysgu

Mae'r Athro Jenkins yn dysgu modiwl 3ydd flwyddyn ar Geneteg Canser, yn seiliedig ar Nodweddion Canser “Hanahan a Weinberg”.

Ymchwil Prif Wobrau Cydweithrediadau

Cyhoeddiadau

Uchafbwyntiau Ymchwil

Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Mowbray, N., Griffiths, R., Akbari, A., Hutchings, H., Jenkins, G., & Al-Sarireh, B. (2022). The Impact of a Centralised Pancreatic Cancer Service: a Case Study of Wales, UK. Journal of Gastrointestinal Surgery, 26(2), 367-375.
https://doi.org/10.1007/s11605-020-04612-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53893
Llewellyn, S., Parak, W., Hühn, J., Burgum, M., Evans, S., Chapman, K., Jenkins, G., Doak, S., & Clift, M. (2022). Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines in vitro. Nanotoxicology, 16(1), 52-72.
https://doi.org/10.1080/17435390.2022.2030823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59210
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Burden, N., Clift, M., Jenkins, G., Labram, B., & Sewell, F. (2021). Opportunities and Challenges for Integrating New In Vitro Methodologies in Hazard Testing and Risk Assessment. Small, 17(15), 2006298
https://doi.org/10.1002/smll.202006298, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56145
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Burgum, M., Clift, M., Evans, S., Hondow, N., Miller, M., Bustamante-Lopez, S., Williams, A., Tarat, A., Jenkins, G., & Doak, S. (2021). In Vitro Primary‐Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few‐Layer Graphene. Small, 17(15), 2002551
https://doi.org/10.1002/smll.202002551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54412
Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.
https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186
Shah, U., Verma, J., Chapman, K., Wilde, E., Tonkin, J., Brown, R., Johnson, G., Doak, S., & Jenkins, G. (2020). Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models. Mutagenesis, 35(6), 445-452.
https://doi.org/10.1093/mutage/geaa029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55770
Dural, E., Shah, U., Pritchard, D., Chapman, K., Doak, S., Jenkins, G., & Jenkins, G. (2020). The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro. Mutagenesis, 35(6), 479-489.
https://doi.org/10.1093/mutage/geaa024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55854
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Clift, M., Jenkins, G., & Doak, S. (2020). An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health. Small, 16(36), 2002002
https://doi.org/10.1002/smll.202002002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54913
Chapman, F., Sparham, C., Hastie, C., Sanders, D., Egmond, R., Chapman, K., Doak, S., Scott, A., & Jenkins, G. (2020). Comparison of passive-dosed and solvent spiked exposures of pro-carcinogen, benzo[a]pyrene, to human lymphoblastoid cell line, MCL-5. Toxicology in Vitro, 67, 104905
https://doi.org/10.1016/j.tiv.2020.104905, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54540
Evans, S., Jenkins, G., Doak, S., & Clift, M. (2019). Cellular Defense Mechanisms Following Nanomaterial Exposure: A Focus on Oxidative Stress and Cytotoxicity. Biological Responses to Nanoscale Particles (pp. 243-254). Springer International Publishing
https://doi.org/10.1007/978-3-030-12461-8_10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50127
Haboubi, H., Lawrence, R., Rees, B., Williams, L., Manson, J., Al-Mossawi, N., Bodger, O., Griffiths, P., Thornton, C., & Jenkins, G. (2019). Developing a blood-based gene mutation assay as a novel biomarker for oesophageal adenocarcinoma. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-41490-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49713
https://www.nature.com/articles/s41598-019-41490-w
Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)
https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861
Wilkinson, T., Jenkins, G., Davies, A., Row, P., Hitchings, M., & Islam, S. (2018). Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study. BMJ Open
https://doi.org/10.1136/bmjopen-2018-021987, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45409
Mowbray, N., Griffiths, R., Akbari, A., Hutchings, H., Jenkins, G., & Al-Sarireh, B. (2018). Centralised pancreatic cancer services: have we made a difference?. HPB, 20, S310-S311.
https://doi.org/10.1016/j.hpb.2018.06.323, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45560
http://dx.doi.org/10.1016/j.hpb.2018.06.323
Kokelaar, R., Jones, H., Williamson, J., Williams, N., Griffiths, A., Beynon, J., Jenkins, G., & Harris, D. (2018). DNA hypermethylation as a predictor of extramural vascular invasion (EMVI) in rectal cancer. Cancer Biology & Therapy, 19(3), 214-221.
https://doi.org/10.1080/15384047.2017.1416933, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49715
Wilde, E., Chapman, K., Stannard, L., Seager, A., Brüsehafer, K., Shah, U., Tonkin, J., Brown, M., Verma, J., Doherty, A., Johnson, G., Doak, S., Jenkins, G., Johnson, G., Jenkins, G., & Brown, R. (2018). A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Archives of Toxicology, 92(2), 935-951.
https://doi.org/10.1007/s00204-017-2102-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36828
Shah, U., Mallia, J., Singh, N., Chapman, K., Doak, S., & Jenkins, G. (2018). A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 825, 51-58.
https://doi.org/10.1016/j.mrgentox.2017.12.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37674
Letsolo, B., Jones, R., Rowson, J., Grimstead, J., Keith, W., Jenkins, G., Baird, D., & Jenkins, G. (2017). Extensive telomere erosion is consistent with localised clonal expansions in Barrett’s metaplasia. PLOS ONE, 12(3), e0174833
https://doi.org/10.1371/journal.pone.0174833, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34160
http://europepmc.org/abstract/med/28362812
Evans, S., Clift, M., Singh, N., De Oliveira Mallia, J., Burgum, M., Wills, J., Wilkinson, T., Jenkins, G., Doak, S., Jenkins, G., Wilkinson, T., & Clift, M. (2017). Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity. Mutagenesis, 32(1), 233-241.
https://doi.org/10.1093/mutage/gew054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33917
https://academic.oup.com/mutage/article/32/1/233/3865764/Critical-review-of-the-current-and-future
Chapman, K., Hoffmann, G., Doak, S., & Jenkins, G. (2017). Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis
https://doi.org/10.1016/j.mrgentox.2017.05.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33260
Rees, D., Crick, P., Jenkins, G., Wang, Y., Griffiths, W., Brown, T., & Al-Sarireh, B. (2017). Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease. The Journal of Steroid Biochemistry and Molecular Biology, 174, 290-295.
https://doi.org/10.1016/j.jsbmb.2017.10.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36199
Manshian, B., Martens, T., Kantner, K., Braeckmans, K., De Smedt, S., Demeester, J., Jenkins, G., Parak, W., Pelaz, B., Doak, S., Himmelreich, U., & Soenen, S. (2017). The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile. Journal of Nanobiotechnology, 15(1)
https://doi.org/10.1186/s12951-017-0279-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37109
http://europepmc.org/abstract/med/28619032
Jones, H., Jenkins, G., Williams, N., Griffiths, P., Chambers, P., Beynon, J., Harris, D., & Jenkins, G. (2017). Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer. World Journal of Surgery, 41(5), 1375-1383.
https://doi.org/10.1007/s00268-016-3860-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34157
http://europepmc.org/abstract/med/28097409
Williamson, J., Jones, H., Williams, N., Griffiths, A., Jenkins, G., Beynon, J., & Harris, D. (2017). Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype. World Journal of Gastrointestinal Oncology, 9(5), 209
https://doi.org/10.4251/wjgo.v9.i5.209, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34156
http://europepmc.org/abstract/med/28567185
Rees, B., Tate, M., Lynch, A., Thornton, C., Jenkins, G., Walmsley, R., & Johnson, G. (2017). Development of anin vitro PIG-Agene mutation assay in human cells. Mutagenesis, 32(2), 283-297.
https://doi.org/10.1093/mutage/gew059, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55073
Rees, B., Tate, M., Lynch, A., Thornton, C., Jenkins, G., Walmsley, R., & Johnson, G. (2017). Development of an in vitro PIG-A gene mutation assay in human cells. Mutagenesis, 32(2), 283-297.
https://doi.org/10.1093/mutage/gew059, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31018
https://academic.oup.com/mutage/article-lookup/doi/10.1093/mutage/gew059
Verma, J., Rees, B., Wilde, E., Thornton, C., Jenkins, G., Doak, S., Johnson, G., Thornton, C., Jenkins, G., & Johnson, G. (2016). Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells. Archives of Toxicology, 91(7), 2689-2698.
https://doi.org/10.1007/s00204-016-1903-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31363
Brüsehafer, K., Manshian, B., Doherty, A., Zaïr, Z., Johnson, G., Doak, S., Jenkins, G., & Bruesehafer, K. (2016). The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency. Mutagenesis, 31(2), 171-180.
https://doi.org/10.1093/mutage/gev069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23828
Stannard, L., Doak, S., Doherty, A., & Jenkins, G. (2016). Is Nickel Chloride really a Non-Genotoxic Carcinogen?. Basic & Clinical Pharmacology & Toxicology
https://doi.org/10.1111/bcpt.12689, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31536
http://europepmc.org/abstract/med/27748567
Shah, U., Seager, A., Fowler, P., Doak, S., Johnson, G., Scott, S., Scott, A., & Jenkins, G. (2016). A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 808, 8-19.
https://doi.org/10.1016/j.mrgentox.2016.06.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29535
Wills, J., Hondow, N., Thomas, A., Chapman, K., Fish, D., Maffeis, T., Penny, M., Brown, R., Jenkins, G., Brown, A., White, P., & Doak, S. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fibre Toxicology, 13(1)
https://doi.org/10.1186/s12989-016-0161-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29852
Ismail, H., Morgan, C., Griffiths, P., Williams, J., & Jenkins, G. (2016). A Newly Developed Nested PCR Assay for the Detection of Helicobacter pylori in the Oral Cavity. Journal of Clinical Gastroenterology, 50(1), 17-22.
https://doi.org/10.1097/MCG.0000000000000310, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20007
Manshian, B., Soenen, S., Al-Ali, A., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Cell Type-Dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints. Toxicological Sciences
https://doi.org/10.1093/toxsci/kfv002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20117
Williamson, J., Harris, D., Beynon, J., & Jenkins, G. (2015). Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer. Clinical Epigenetics, 7(1)
https://doi.org/10.1186/s13148-015-0111-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23399
Chapman, K., Doak, S., Jenkins, G., Jenkins, G., Doak, S., & Chapman, K. (2015). Acute Dosing and p53-Deficiency Promote Cellular Sensitivity to DNA Methylating Agents. Toxicological Sciences, 144(2), 357-365.
https://doi.org/10.1093/toxsci/kfv004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20121
McAdam, E., Haboubi, H., Griffiths, A., Baxter, J., Spencer-Harty, S., Davies, C., Jenkins, G., & Jenkins, G. (2015). Reflux composition influences the level of NF-κB activation and upstream kinase preference in oesophageal adenocarcinoma cells. International Journal of Cancer, 136, 527-535.
https://doi.org/10.1002/ijc.29029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18151
Manshian, B., Soenen, S., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries. Mutagenesis, gev061
https://doi.org/10.1093/mutage/gev061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26170
http://europepmc.org/abstract/med/26275419
Jenkins, G. (2014). Genotoxins induce binucleation in L5178Y and TK6 cells. Mutation Research Genetic Toxicology, 770, 29-34.
https://doi.org/10.1016/j.mrgentox.2014.05.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18154
Jenkins, G., Doak, S., & Bruesehafer, K. (2014). Chromosome Breakage Induced by the Genotoxic Agents Mitomycin C and Cytosine arabinoside. Toxicological Sciences, 140(1), 94-102.
https://doi.org/10.1093/toxsci/kfu058, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18150
Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.
https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804
Jenkins, G., Doak, S., & Chapman, K. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm human reconstructed skin. Mutagenesis, 29(3), 165-175.
https://doi.org/10.1093/mutage/geu011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18153
Doak, S., Jenkins, G., & Haboubi, H. (2013). The jury is still out on the safety of silver nanoparticles. BMJ, 346(jan15 4), f227-f227.
https://doi.org/10.1136/bmj.f227, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17516
Manshian, B., Jenkins, G., Williams, P., Wright, C., Barron, A., Brown, A., Hondow, N., Dunstan, P., Rickman, R., Brady, K., Doak, S., & Wright, C. (2013). Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties. Nanotoxicology, 7(2), 144-156.
https://doi.org/10.3109/17435390.2011.647928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7295
Zaïr, Z., Johnson, G., Griffiths, A., Jenkins, G., Jenkins, G., & Johnson, G. (2013). Diagnostic correlation between the expression of the DNA repair enzymeN-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study. Diseases of the Esophagus, 26(6), 644-650.
https://doi.org/10.1111/dote.12003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13243
Thomas, A., Jenkins, G., Kaina, B., Bodger, O., Tomaszowski, K., Lewis, P., Doak, S., Johnson, G., Jenkins, G., Lewis, P., Doak, S., Bodger, O., & Johnson, G. (2013). Influence of DNA Repair on Nonlinear Dose-Responses for Mutation. Toxicological Sciences, 132(1), 87-95.
https://doi.org/10.1093/toxsci/kfs341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13715

Holl Ymchwil

Erthyglau Cylchgronau

Meuser, E., Chang, K., Walters, A., Hurley, J., West, H., Perry, I., Mort, M., Reyes-Uribe, L., Truscott, R., Jones, N., Lawrence, R., Jenkins, G., Giles, P., Dolwani, S., Al-Sarireh, B., Hawkes, N., Short, E., Williams, G., Taggart, M...., & Thomas, L. (2024). PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis. Molecular Cancer Research, 22(6), 515-523.
https://doi.org/10.1158/1541-7786.mcr-23-0810, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65964
Naser, H., Munn, K., Lawrence, R., Wright, R., GREWAL, E., Williams, L., Doak, S., & Jenkins, G. (2024). Human plasma can modulate micronucleus frequency in TK6 and OE33 cells in vitro. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 896, 503766
https://doi.org/10.1016/j.mrgentox.2024.503766, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa66474
Chapman, K., Shah, U., Fletcher, J., Johnson, G., Doak, S., & Jenkins, G. (2024). An integrated in vitro carcinogenicity test that distinguishes between genotoxic carcinogens, non-genotoxic carcinogens, and non-carcinogens. Mutagenesis, 39(2), 69-77.
https://doi.org/10.1093/mutage/geae004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65653
Stannard, L., Doherty, A., Chapman, K., Doak, S., Jenkins, G., & Stannard, L. (2024). Multi-endpoint analysis of cadmium chloride-induced genotoxicity shows role for reactive oxygen species and p53 activation in DNA damage induction, cell cycle irregularities, and cell size aberrations. Mutagenesis, 39(1), 13-23.
https://doi.org/10.1093/mutage/gead025, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa64199
Lawrence, R., Munn, K., Naser, H., Thomas, L., Haboubi, H., Williams, L., Doak, S., & Jenkins, G. (2023). The PIG-A gene mutation assay in human biomonitoring and disease. Environmental and Molecular Mutagenesis, 64(8-9), 480-493.
https://doi.org/10.1002/em.22577, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa65085
Llewellyn, S., Kermanizadeh, A., Ude, V., Jacobsen, N., Conway, G., Shah, U., Niemeijer, M., Moné, M., Water, B., Roy, S., Moritz, W., Stone, V., Jenkins, G., & Doak, S. (2022). Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids. Toxicology in Vitro, 85, 105473
https://doi.org/10.1016/j.tiv.2022.105473, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa61191
Evans, S., Lawrence, R., Ilett, M., Burgum, M., Meldrum, K., Hondow, N., Jenkins, G., Clift, M., & Doak, S. (2022). Industrial-relevant TiO2 types do not promote cytotoxicity in the A549 or TK6 cell lines regardless of cell specific interaction. Toxicology in Vitro, 83, 105415
https://doi.org/10.1016/j.tiv.2022.105415, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa60312
Mowbray, N., Griffiths, R., Akbari, A., Hutchings, H., Jenkins, G., & Al-Sarireh, B. (2022). The Impact of a Centralised Pancreatic Cancer Service: a Case Study of Wales, UK. Journal of Gastrointestinal Surgery, 26(2), 367-375.
https://doi.org/10.1007/s11605-020-04612-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa53893
Llewellyn, S., Parak, W., Hühn, J., Burgum, M., Evans, S., Chapman, K., Jenkins, G., Doak, S., & Clift, M. (2022). Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines in vitro. Nanotoxicology, 16(1), 52-72.
https://doi.org/10.1080/17435390.2022.2030823, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa59210
Llewellyn, S., Conway, G., Zanoni, I., Jørgensen, A., Shah, U., Seleci, D., Keller, J., Kim, J., Wohlleben, W., Jensen, K., Costa, A., Jenkins, G., Clift, M., & Doak, S. (2021). Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver. Journal of Nanobiotechnology, 19(1)
https://doi.org/10.1186/s12951-021-00938-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa57237
Burden, N., Clift, M., Jenkins, G., Labram, B., & Sewell, F. (2021). Opportunities and Challenges for Integrating New In Vitro Methodologies in Hazard Testing and Risk Assessment. Small, 17(15), 2006298
https://doi.org/10.1002/smll.202006298, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56145
Llewellyn, S., Niemeijer, M., Nymark, P., Moné, M., Water, B., Conway, G., Jenkins, G., & Doak, S. (2021). In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment. Small, 17(15), 2006055
https://doi.org/10.1002/smll.202006055, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa56073
Burgum, M., Clift, M., Evans, S., Hondow, N., Miller, M., Bustamante-Lopez, S., Williams, A., Tarat, A., Jenkins, G., & Doak, S. (2021). In Vitro Primary‐Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few‐Layer Graphene. Small, 17(15), 2002551
https://doi.org/10.1002/smll.202002551, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54412
Chapman, K., Wilde, E., Chapman, F., Verma, J., Shah, U., Stannard, L., Seager, A., Tonkin, J., Brown, R., Doherty, A., Johnson, G., Doak, S., & Jenkins, G. (2021). Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action. Archives of Toxicology, 95(1), 321-336.
https://doi.org/10.1007/s00204-020-02902-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55186
Shah, U., Verma, J., Chapman, K., Wilde, E., Tonkin, J., Brown, R., Johnson, G., Doak, S., & Jenkins, G. (2020). Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models. Mutagenesis, 35(6), 445-452.
https://doi.org/10.1093/mutage/geaa029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55770
Dural, E., Shah, U., Pritchard, D., Chapman, K., Doak, S., Jenkins, G., & Jenkins, G. (2020). The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro. Mutagenesis, 35(6), 479-489.
https://doi.org/10.1093/mutage/geaa024, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55854
Conway, G., Shah, U., Llewellyn, S., Cervena, T., Evans, S., Al-Ali, A., Jenkins, G., Clift, M., & Doak, S. (2020). Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations. Mutagenesis, 35(4), 319-329.
https://doi.org/10.1093/mutage/geaa018, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54991
Clift, M., Jenkins, G., & Doak, S. (2020). An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health. Small, 16(36), 2002002
https://doi.org/10.1002/smll.202002002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54913
Chapman, F., Sparham, C., Hastie, C., Sanders, D., Egmond, R., Chapman, K., Doak, S., Scott, A., & Jenkins, G. (2020). Comparison of passive-dosed and solvent spiked exposures of pro-carcinogen, benzo[a]pyrene, to human lymphoblastoid cell line, MCL-5. Toxicology in Vitro, 67, 104905
https://doi.org/10.1016/j.tiv.2020.104905, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54540
Llewellyn, S., Conway, G., Shah, U., Evans, S., Jenkins, G., Clift, M., & Doak, S. (2020). Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure. Journal of Visualized Experiments(160)
https://doi.org/10.3791/61141, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa54416
Haboubi, H., Lawrence, R., Rees, B., Williams, L., Manson, J., Al-Mossawi, N., Bodger, O., Griffiths, P., Thornton, C., & Jenkins, G. (2019). Developing a blood-based gene mutation assay as a novel biomarker for oesophageal adenocarcinoma. Scientific Reports, 9(1)
https://doi.org/10.1038/s41598-019-41490-w, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49713
https://www.nature.com/articles/s41598-019-41490-w
Evans, S., Clift, M., Singh, N., Wills, J., Hondow, N., Wilkinson, T., Burgum, M., Brown, A., Jenkins, G., & Doak, S. (2019). In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials. Particle and Fibre Toxicology, 16(1)
https://doi.org/10.1186/s12989-019-0291-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa48861
Wilkinson, T., Jenkins, G., Davies, A., Row, P., Hitchings, M., & Islam, S. (2018). Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study. BMJ Open
https://doi.org/10.1136/bmjopen-2018-021987, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45409
Mowbray, N., Griffiths, R., Akbari, A., Hutchings, H., Jenkins, G., & Al-Sarireh, B. (2018). Centralised pancreatic cancer services: have we made a difference?. HPB, 20, S310-S311.
https://doi.org/10.1016/j.hpb.2018.06.323, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa45560
http://dx.doi.org/10.1016/j.hpb.2018.06.323
Kokelaar, R., Jones, H., Williamson, J., Williams, N., Griffiths, A., Beynon, J., Jenkins, G., & Harris, D. (2018). DNA hypermethylation as a predictor of extramural vascular invasion (EMVI) in rectal cancer. Cancer Biology & Therapy, 19(3), 214-221.
https://doi.org/10.1080/15384047.2017.1416933, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49715
Wilde, E., Chapman, K., Stannard, L., Seager, A., Brüsehafer, K., Shah, U., Tonkin, J., Brown, M., Verma, J., Doherty, A., Johnson, G., Doak, S., Jenkins, G., Johnson, G., Jenkins, G., & Brown, R. (2018). A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Archives of Toxicology, 92(2), 935-951.
https://doi.org/10.1007/s00204-017-2102-y, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36828
Shah, U., Mallia, J., Singh, N., Chapman, K., Doak, S., & Jenkins, G. (2018). A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 825, 51-58.
https://doi.org/10.1016/j.mrgentox.2017.12.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37674
Letsolo, B., Jones, R., Rowson, J., Grimstead, J., Keith, W., Jenkins, G., Baird, D., & Jenkins, G. (2017). Extensive telomere erosion is consistent with localised clonal expansions in Barrett’s metaplasia. PLOS ONE, 12(3), e0174833
https://doi.org/10.1371/journal.pone.0174833, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34160
http://europepmc.org/abstract/med/28362812
Evans, S., Clift, M., Singh, N., De Oliveira Mallia, J., Burgum, M., Wills, J., Wilkinson, T., Jenkins, G., Doak, S., Jenkins, G., Wilkinson, T., & Clift, M. (2017). Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity. Mutagenesis, 32(1), 233-241.
https://doi.org/10.1093/mutage/gew054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33917
https://academic.oup.com/mutage/article/32/1/233/3865764/Critical-review-of-the-current-and-future
Chapman, K., Hoffmann, G., Doak, S., & Jenkins, G. (2017). Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N -methyl- N -nitrosourea. Mutation Research/Genetic Toxicology and Environmental Mutagenesis
https://doi.org/10.1016/j.mrgentox.2017.05.002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa33260
Rees, D., Crick, P., Jenkins, G., Wang, Y., Griffiths, W., Brown, T., & Al-Sarireh, B. (2017). Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease. The Journal of Steroid Biochemistry and Molecular Biology, 174, 290-295.
https://doi.org/10.1016/j.jsbmb.2017.10.011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa36199
Manshian, B., Martens, T., Kantner, K., Braeckmans, K., De Smedt, S., Demeester, J., Jenkins, G., Parak, W., Pelaz, B., Doak, S., Himmelreich, U., & Soenen, S. (2017). The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile. Journal of Nanobiotechnology, 15(1)
https://doi.org/10.1186/s12951-017-0279-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa37109
http://europepmc.org/abstract/med/28619032
Jones, H., Jenkins, G., Williams, N., Griffiths, P., Chambers, P., Beynon, J., Harris, D., & Jenkins, G. (2017). Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer. World Journal of Surgery, 41(5), 1375-1383.
https://doi.org/10.1007/s00268-016-3860-z, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34157
http://europepmc.org/abstract/med/28097409
Williamson, J., Jones, H., Williams, N., Griffiths, A., Jenkins, G., Beynon, J., & Harris, D. (2017). Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype. World Journal of Gastrointestinal Oncology, 9(5), 209
https://doi.org/10.4251/wjgo.v9.i5.209, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa34156
http://europepmc.org/abstract/med/28567185
Rees, B., Tate, M., Lynch, A., Thornton, C., Jenkins, G., Walmsley, R., & Johnson, G. (2017). Development of anin vitro PIG-Agene mutation assay in human cells. Mutagenesis, 32(2), 283-297.
https://doi.org/10.1093/mutage/gew059, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa55073
Rees, B., Tate, M., Lynch, A., Thornton, C., Jenkins, G., Walmsley, R., & Johnson, G. (2017). Development of an in vitro PIG-A gene mutation assay in human cells. Mutagenesis, 32(2), 283-297.
https://doi.org/10.1093/mutage/gew059, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31018
https://academic.oup.com/mutage/article-lookup/doi/10.1093/mutage/gew059
Verma, J., Rees, B., Wilde, E., Thornton, C., Jenkins, G., Doak, S., Johnson, G., Thornton, C., Jenkins, G., & Johnson, G. (2016). Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells. Archives of Toxicology, 91(7), 2689-2698.
https://doi.org/10.1007/s00204-016-1903-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31363
Brüsehafer, K., Manshian, B., Doherty, A., Zaïr, Z., Johnson, G., Doak, S., Jenkins, G., & Bruesehafer, K. (2016). The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency. Mutagenesis, 31(2), 171-180.
https://doi.org/10.1093/mutage/gev069, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23828
Stannard, L., Doak, S., Doherty, A., & Jenkins, G. (2016). Is Nickel Chloride really a Non-Genotoxic Carcinogen?. Basic & Clinical Pharmacology & Toxicology
https://doi.org/10.1111/bcpt.12689, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa31536
http://europepmc.org/abstract/med/27748567
Shah, U., Seager, A., Fowler, P., Doak, S., Johnson, G., Scott, S., Scott, A., & Jenkins, G. (2016). A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 808, 8-19.
https://doi.org/10.1016/j.mrgentox.2016.06.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29535
Wills, J., Hondow, N., Thomas, A., Chapman, K., Fish, D., Maffeis, T., Penny, M., Brown, R., Jenkins, G., Brown, A., White, P., & Doak, S. (2016). Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™). Particle and Fibre Toxicology, 13(1)
https://doi.org/10.1186/s12989-016-0161-5, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa29852
Ismail, H., Morgan, C., Griffiths, P., Williams, J., & Jenkins, G. (2016). A Newly Developed Nested PCR Assay for the Detection of Helicobacter pylori in the Oral Cavity. Journal of Clinical Gastroenterology, 50(1), 17-22.
https://doi.org/10.1097/MCG.0000000000000310, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20007
Manshian, B., Soenen, S., Al-Ali, A., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Cell Type-Dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints. Toxicological Sciences
https://doi.org/10.1093/toxsci/kfv002, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20117
Williamson, J., Harris, D., Beynon, J., & Jenkins, G. (2015). Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer. Clinical Epigenetics, 7(1)
https://doi.org/10.1186/s13148-015-0111-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23399
Chapman, K., Doak, S., Jenkins, G., Jenkins, G., Doak, S., & Chapman, K. (2015). Acute Dosing and p53-Deficiency Promote Cellular Sensitivity to DNA Methylating Agents. Toxicological Sciences, 144(2), 357-365.
https://doi.org/10.1093/toxsci/kfv004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20121
McAdam, E., Haboubi, H., Griffiths, A., Baxter, J., Spencer-Harty, S., Davies, C., Jenkins, G., & Jenkins, G. (2015). Reflux composition influences the level of NF-κB activation and upstream kinase preference in oesophageal adenocarcinoma cells. International Journal of Cancer, 136, 527-535.
https://doi.org/10.1002/ijc.29029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18151
Manshian, B., Soenen, S., Brown, A., Hondow, N., Wills, J., Jenkins, G., Doak, S., Jenkins, G., & Doak, S. (2015). Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries. Mutagenesis, gev061
https://doi.org/10.1093/mutage/gev061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa26170
http://europepmc.org/abstract/med/26275419
Jenkins, G. (2014). Genotoxins induce binucleation in L5178Y and TK6 cells. Mutation Research Genetic Toxicology, 770, 29-34.
https://doi.org/10.1016/j.mrgentox.2014.05.005, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18154
Jenkins, G., Doak, S., & Bruesehafer, K. (2014). Chromosome Breakage Induced by the Genotoxic Agents Mitomycin C and Cytosine arabinoside. Toxicological Sciences, 140(1), 94-102.
https://doi.org/10.1093/toxsci/kfu058, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18150
Seager, A., Shah, U., Brusehafer, K., Wills, J., Manshian, B., Chapman, K., Thomas, A., Scott, A., Doherty, A., Doak, S., Johnson, G., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., Bruesehafer, K., Shah, U., & Chapman, K. (2014). Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells. Mutagenesis, 29(3), 155-164.
https://doi.org/10.1093/mutage/geu008, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17804
Jenkins, G., Doak, S., & Chapman, K. (2014). Automation and validation of micronucleus detection in the 3D EpiDerm human reconstructed skin. Mutagenesis, 29(3), 165-175.
https://doi.org/10.1093/mutage/geu011, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa18153
Doak, S., Jenkins, G., & Haboubi, H. (2013). The jury is still out on the safety of silver nanoparticles. BMJ, 346(jan15 4), f227-f227.
https://doi.org/10.1136/bmj.f227, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17516
Manshian, B., Jenkins, G., Williams, P., Wright, C., Barron, A., Brown, A., Hondow, N., Dunstan, P., Rickman, R., Brady, K., Doak, S., & Wright, C. (2013). Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties. Nanotoxicology, 7(2), 144-156.
https://doi.org/10.3109/17435390.2011.647928, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa7295
Zaïr, Z., Johnson, G., Griffiths, A., Jenkins, G., Jenkins, G., & Johnson, G. (2013). Diagnostic correlation between the expression of the DNA repair enzymeN-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study. Diseases of the Esophagus, 26(6), 644-650.
https://doi.org/10.1111/dote.12003, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13243
Thomas, A., Jenkins, G., Kaina, B., Bodger, O., Tomaszowski, K., Lewis, P., Doak, S., Johnson, G., Jenkins, G., Lewis, P., Doak, S., Bodger, O., & Johnson, G. (2013). Influence of DNA Repair on Nonlinear Dose-Responses for Mutation. Toxicological Sciences, 132(1), 87-95.
https://doi.org/10.1093/toxsci/kfs341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13715
McAdam, E., Haboubi, H., Forrester, G., Eltahir, Z., Spencer-Harty, S., Davies, C., Griffiths, A., Baxter, J., Jenkins, G., Jenkins, G., & Haboubi, H. (2012). Inducible Nitric Oxide Synthase (iNOS) and Nitric Oxide (NO) are Important Mediators of Reflux-induced Cell Signalling in Esophageal Cells. Carcinogenesis, 33, 2035
https://doi.org/10.1093/carcin/bgs241, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12373
Johnson, G., Zair, Z., Bodger, O., Lewis, P., Rees, B., Verma, J., Thomas, A., Doak, S., & Jenkins, G. (2012). Investigating Mechanisms for Non-linear Genotoxic Responses, and Analysing Their Effects in Binary Combination. Genes and Environment, 34(4), 179-185.
https://doi.org/10.3123/jemsge.34.179, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa13400
Seager, A., Shah, U., Mikhail, J., Nelson, B., Marquis, B., Doak, S., Johnson, G., Griffiths, S., Carmichael, P., Scott, S., Scott, A., Jenkins, G., Jenkins, G., Doak, S., Seager, A., Johnson, G., & Mikhail, J. (2012). Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance. Toxicological Sciences, 128(2), 387-397.
https://doi.org/10.1093/toxsci/kfs152, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10909
http://toxsci.oxfordjournals.org/content/early/2012/04/26/toxsci.kfs152.abstract
Doak, S., Manshian, B., Jenkins, G., Singh, N., Jenkins, G., & Doak, S. (2012). In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 745(1-2), 104
https://doi.org/10.1016/j.mrgentox.2011.09.013, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10472
Rawat, N., Alhamdani, A., McAdam, E., Cronin, J., Eltahir, Z., Lewis, P., Griffiths, P., Baxter, J., & Jenkins, G. (2012). Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett’s oesophagus. Clinical and Translational Oncology, 14(4), 302-311.
https://doi.org/10.1007/s12094-012-0799-x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12971
Singh, N., Jenkins, G., Nelson, B., Marquis, B., Maffeis, T., Brown, A., Williams, P., Wright, C., Doak, S., & Wright, C. (2012). The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles. Biomaterials, 33(1), 163
https://doi.org/10.1016/j.biomaterials.2011.09.087, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa14121
Hughes, R., Parry, J., Beynon, J., Jenkins, G., & Jenkins, G. (2011). Molecular changes consistent with increased proliferation and invasion are common in rectal cancer. Clinical and Translational Oncology, 13(10), 753-759.
https://doi.org/10.1007/s12094-011-0728-4, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23410
http://www.scopus.com/inward/record.url?eid=2-s2.0-81255165913&partnerID=MN8TOARS
Cronin, J., Alhamdani, A., Griffiths, A., Baxter, J., Brown, T., Jenkins, G., Jenkins, G., & Cronin, J. (2011). In vitro and ex vivo models of extended reflux exposure demonstrate that weakly acidic mixed reflux heightens NF-kB-mediated gene expression. Diseases of the Esophagus, 24(5), 360-370.
https://doi.org/10.1111/j.1442-2050.2010.01148.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12975
Griffiths, S., Singh, N., Jenkins, G., Wright, C., Jenkins, G., Williams, P., Doak, S., & Orbaek White, A. (2011). Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes.. Analytical Chemistry, 83(10), 3778-3785.
https://doi.org/10.1021/ac200103x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10082
Zair, Z., Jenkins, G., Doak, S., Singh, R., Brown, K., Johnson, G., Jenkins, G., Doak, S., & Johnson, G. (2011). N-Methylpurine DNA Glycosylase Plays a Pivotal Role in the Threshold Response of Ethyl Methanesulfonate-Induced Chromosome Damage. Toxicological Sciences, 119(2), 346-358.
https://doi.org/10.1093/toxsci/kfq341, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10158
Cronin, J., McAdam, E., Danikas, A., Tselepis, C., Griffiths, P., Baxter, J., Thomas, L., Manson, J., & Jenkins, G. (2011). Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in High-Grade Dysplasia and Adenocarcinoma of the Esophagus and May Represent a Biomarker of Histological Progression in Barrett's Esophagus (BE). The American Journal of Gastroenterology, 106(1), 46
https://doi.org/10.1038/ajg.2010.433, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9800
Jenkins, G., Zaïr, Z., Johnson, G., & Doak, S. (2010). Genotoxic thresholds, DNA repair, and susceptibility in human populations. Toxicology, 278(3), 305-310.
https://doi.org/10.1016/j.tox.2009.11.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9893
Johnson, G., Jenkins, G., Thomas, A., & Doak, S. (2010). Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 702(2), 189-192.
https://doi.org/10.1016/j.mrgentox.2009.07.014, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9258
Singh, N., Jenkins, G., Asadi, R., & Doak, S. (2010). Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Reviews, 1(1), 5358
https://doi.org/10.3402/nano.v1i0.5358, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49717
Cronin, J., Williams, L., McAdam, E., Eltahir, Z., Griffiths, P., Baxter, J., & Jenkins, G. (2010). The role of secondary bile acids in neoplastic development in the oesophagus. Biochemical Society Transactions, 38(2), 337
https://doi.org/10.1042/BST0380337, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa12976
Johnson, G., Doak, S., Griffiths, S., & Jenkins, G. (2009). Non-linear dose¨Cresponse of DNA-reactive genotoxins: Recommendations for data analysis.. Mutat. Res. (Gen. Tox), 678, 95-100.
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10105
Williams, L., Somasekar, A., Davies, D., Cronin, J., Doak, S., Alcolado, R., Williams, J., Griffiths, A., Baxter, J., Jenkins, G., Jenkins, G., Cronin, J., Williams, J., & Baxter, J. (2009). Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 669(1-2), 104
https://doi.org/10.1016/j.mrfmmm.2009.05.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9801
Singh, N., Manshian, B., Jenkins, G., Griffiths, S., Williams, P., Maffeis, T., Wright, C., Doak, S., & Wright, C. (2009). NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials. Biomaterials, 30(23-24), 3891-3914.
https://doi.org/10.1016/j.biomaterials.2009.04.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10709
Johnson, G., Doak, S., Griffiths, S., Quick, E., Skibinski, D., Zaïr, Z., & Jenkins, G. (2009). Non-linear dose–response of DNA-reactive genotoxins: Recommendations for data analysis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 678(2), 95-100.
https://doi.org/10.1016/j.mrgentox.2009.05.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10159
http://www.scopus.com/record/display.url?eid=2-s2.0-69449087034&origin=resultslist&sort=plf-f&src=s&st1=johnson&st2=g&nlo=1&nlr=20&nls=count-f&sid=nkEabDC5JfN4WVqV93wmb74%3a163&sot=anl&sdt=aut&sl=38&s=AU-ID%28%22Johnson%2c+George+E.%22+8528864100%29&relpos=4&relpos=4&searchTerm=AU-ID(\%22Johnson,%20George%20E.\%22%208528864100)
Doak, S., Griffiths, S., Manshian, B., Singh, N., Williams, P., Brown, A., Jenkins, G., & Jenkins, G. (2009). Confounding experimental considerations in nanogenotoxicology. Mutagenesis, 24(4), 285-293.
https://doi.org/10.1093/mutage/gep010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10103
Doak, S., Griffiths, S., Manshian, B., Singh, N., Williams, P., Brown, A., Jenkins, G., Jenkins, G., Williams, P., & Doak, S. (2009). Confounding experimental considerations in nanogenotoxicology. Mutagenesis, 24(4), 285
https://doi.org/10.1093/mutage/gep010, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9847
Rai, N., Jenkins, G., McAdam, E., Hibbitts, S., Fiander, A., Powell, N., & Jenkins, G. (2008). Human papillomavirus infection in Barrett's oesophagus in the UK: An infrequent event. Journal of Clinical Virology, 43(2), 250-252.
https://doi.org/10.1016/j.jcv.2008.07.004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23427
http://www.scopus.com/inward/record.url?eid=2-s2.0-50849138490&partnerID=MN8TOARS
Beasley, W., Beynon, J., Jenkins, G., Parry, J., & Jenkins, G. (2008). Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case–control disease association study. International Journal of Colorectal Disease, 23(4), 375-381.
https://doi.org/10.1007/s00384-007-0435-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23425
http://www.scopus.com/inward/record.url?eid=2-s2.0-42649102634&partnerID=MN8TOARS
Doak, S., Brüsehafer, K., Dudley, E., Quick, E., Johnson, G., Newton, R., & Jenkins, G. (2008). No-observed effect levels are associated with up-regulation of MGMT following MMS exposure. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 648(1-2), 9-14.
https://doi.org/10.1016/j.mrfmmm.2008.09.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10106
Doak, S., Brusehafer, K., Dudley, E., Jenkins, G., Dudley, E., Doak, S., Johnson, G., & Bruesehafer, K. (2008). No-observed effect levels are associated with up-regulation of MGMT following MMS Exposure. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS ??, 648(1-2), 9-14.
https://doi.org/10.1016/j.mrfmmm.2008.09.016, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10127
Jenkins, G., Cronin, J., Alhamdani, A., Rawat, N., D'Souza, F., Thomas, T., Eltahir, Z., Griffiths, A., Baxter, J., & Jenkins, G. (2008). The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF- B activation in oesophageal cells, with a mechanism of action involving ROS. Mutagenesis, 23(5), 399-405.
https://doi.org/10.1093/mutage/gen029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa10107
Baxter, J., Jenkins, G., & Cronin, J. (2008). The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS. , 23(5), 399-405.
https://doi.org/10.1093/mutage/gen029, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa9803
Ivil, K., Jenkins, S., Doak, S., Hawizy, A., Kynaston, H., Parry, E., Jenkins, G., Parry, J., Stephenson, T., & Jenkins, G. (2007). Identification of Early p53 Mutations in Clam Ileocystoplasties Using Restriction Site Mutation Assay. Urology, 70(5), 905-909.
https://doi.org/10.1016/j.urology.2007.06.1121, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23432
http://www.scopus.com/inward/record.url?eid=2-s2.0-36549071155&partnerID=MN8TOARS
Doak, S., Jenkins, G., Johnson, G., Quick, E., Parry, E., Parry, J., Jenkins, G., Doak, S., & Johnson, G. (2007). Mechanistic Influences for Mutation Induction Curves after Exposure to DNA-Reactive Carcinogens. Cancer Research, 67(8), 3904-3911.
https://doi.org/10.1158/0008-5472.CAN-06-4061, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17856
Jenkins, G., D'Souza, F., Suzen, S., Eltahir, Z., James, S., Parry, J., Griffiths, P., Baxter, J., & Jenkins, G. (2007). Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: the potential role of anti-oxidants in Barrett's oesophagus. Carcinogenesis, 28(1), 136-142.
https://doi.org/10.1093/carcin/bgl147, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1390
Mikhail, J. & Jenkins, G. (2007). Immunohistochemical study of nuclear factor-κB activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers.
https://doi.org/10.1136/jcp.2006.043976, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa20084
Jenkins, G., Jenkins, G., & Johnson, G. (2005). Do dose response thresholds exist for genotoxic alkylating agents?. Mutagenesis, 20(6), 389-398.
https://doi.org/10.1093/mutage/gei054, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa17861
Williams, L., Jenkins, G., Doak, S., Fowler, P., Parry, E., Brown, T., Griffiths, A., Williams, J., Parry, J., & Jenkins, G. (2005). Fluorescence in situ hybridisation analysis of chromosomal aberrations in gastric tissue: the potential involvement of Helicobacter pylori. British Journal of Cancer, 92(9), 1759-1766.
https://doi.org/10.1038/sj.bjc.6602533, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1391
Doak, S., Saidely, D., Jenkins, G., Parry, E., Griffiths, A., Baxter, J., Parry, J., & Jenkins, G. (2004). Generation of locus-specific probes for interphase fluorescence in situ hybridisation—application in Barrett's esophagus. Experimental and Molecular Pathology, 77(1), 26-33.
https://doi.org/10.1016/j.yexmp.2004.04.001, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23435
http://www.scopus.com/inward/record.url?eid=2-s2.0-3042600728&partnerID=MN8TOARS
Jenkins, G. & Jenkins, G. (2004). REVIEW The restriction site mutation (RSM) method: clinical applications. Mutagenesis, 19(1), 3-11.
https://doi.org/10.1093/mutage/geg037, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23434
http://www.scopus.com/inward/record.url?eid=2-s2.0-0346463144&partnerID=MN8TOARS
Doak, S., Jenkins, G., & Doak, S. (2004). Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus—their association with aneuploidy and neoplastic progression. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 547(1-2), 133
https://doi.org/10.1016/j.mrfmmm.2003.12.009, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1408
Jenkins, G. & Jenkins, G. (2004). The bile acid deoxycholic acid (DCA) at neutral pH activates NF- B and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis, 25(3), 317-323.
https://doi.org/10.1093/carcin/bgh032, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1389
Doak, S., Jenkins, G., Parry, E., Griffiths, A., Shah, V., Baxter, J., Parry, J., Jenkins, G., Doak, S., & Baxter, J. (2003). Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma. British Journal of Cancer, 89(9), 1729-1735.
https://doi.org/10.1038/sj.bjc.6601323, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1363
Morgan, C., Jenkins, G., Ashton, T., Griffiths, A., Baxter, J., Parry, E., Parry, J., Jenkins, G., Morgan, C., & Baxter, J. (2003). Detection of p53 mutations in precancerous gastric tissue. British Journal of Cancer, 89(7), 1314-1319.
https://doi.org/10.1038/sj.bjc.6601302, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1365
Doak, S., Jenkins, G., & Doak, S. (2003). Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus. Gut, 52(5), 623-628.
https://doi.org/10.1136/gut.52.5.623, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1388
Jenkins, G., Doak, S., Griffiths, A., Tofazzal, N., Shah, V., Baxter, J., Parry, J., Jenkins, G., & Baxter, J. (2003). Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology. British Journal of Cancer, 88(8), 1271-1276.
https://doi.org/10.1038/sj.bjc.6600891, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa1362
Croft, J., Parry, E., Jenkins, G., Doak, S., Baxter, J., Griffiths, A., Brown, T., Parry, J., & Jenkins, G. (2002). Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridization. European Journal of Gastroenterology & Hepatology, 14(11), 1179-1186.
https://doi.org/10.1097/00042737-200211000-00004, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23443
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036866676&partnerID=MN8TOARS
Jenkins, G., Doak, S., Parry, J., D'Souza, F., Griffiths, A., Baxter, J., & Jenkins, G. (2002). Genetic pathways involved in the progression of Barrett's metaplasia to adenocarcinoma. British Journal of Surgery, 89(7), 824-837.
https://doi.org/10.1046/j.1365-2168.2002.02107.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23442
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036066913&partnerID=MN8TOARS
Jenkins, G., Stephens, L., Masnavi, N., Parry, J., & Jenkins, G. (2002). Molecular analysis of the chemoprotective effects of topical sunscreen and vitamin C in preventing UV-induced and reactive oxygen species-induced DNA damage, respectively, using the PCR inhibition methodology. , 22
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23441
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036875693&partnerID=MN8TOARS
Jenkins, G., Williams, G., Beynon, J., Ye, Z., Baxter, J., Parry, J., & Jenkins, G. (2002). Restriction enzymes in the analysis of genetic alterations responsible for cancer progression. British Journal of Surgery, 89(1), 8-20.
https://doi.org/10.1046/j.0007-1323.2001.01968.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23440
http://www.scopus.com/inward/record.url?eid=2-s2.0-0036135218&partnerID=MN8TOARS
Song, H., Jenkins, G., Ashby, J., Tinwell, H., Parry, J., & Jenkins, G. (2001). The application of the restriction site mutation assay to compare 1-ethyl-1-nitrosourea-induced mutations between the endogenous p53 gene and the transgenic LacZ gene in MutaMouse testes. , 16
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23445
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035163880&partnerID=MN8TOARS
Jenkins, G., Morgan, C., Baxter, J., Parry, E., Parry, J., & Jenkins, G. (2001). The detection of mutations induced in vitro in the human p53 gene by hydrogen peroxide with the restriction site mutation (RSM) assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 498(1-2), 135-144.
https://doi.org/10.1016/S1383-5718(01)00281-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23444
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035889631&partnerID=MN8TOARS
Song, H. & Jenkins, G. (2001). The application of the restriction site mutation assay to compare 1-ethyl-1-nitrosourea-induced mutations between the endogenous p53 gene and the transgenic LacZ gene in MutaMouse testes. Mutagenesis, 16(1), 59-64.
https://doi.org/10.1093/mutage/16.1.59, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49719
Jenkins, G. & Parry, J. (2000). PCR-Based Methodology for the Determination of the Photoprotection Afforded by Sunscreen Application. BioTechniques, 29(6), 1318-1326.
https://doi.org/10.2144/00296rr03, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49720
Sueiro, R., Jenkins, G., Lyons, B., Harvey, J., Parry, J., & Jenkins, G. (2000). Genotypic mutation analysis in the p53 gene of benzo[a]pyrene-treated European flounder (Platichthys flesus). Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 468(1), 63-71.
https://doi.org/10.1016/S1383-5718(00)00040-1, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23450
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034702363&partnerID=MN8TOARS
Parry, J., Jenkins, G., Haddad, F., Bourner, R., Parry, E., & Jenkins, G. (2000). In vitro and in vivo extrapolations of genotoxin exposures: consideration of factors which influence dose–response thresholds. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 464(1), 53-63.
https://doi.org/10.1016/S1383-5718(99)00166-7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23449
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033960142&partnerID=MN8TOARS
Jenkins, G., Parry, J., & Jenkins, G. (2000). PCR-based methodology for the determination of the photoprotection afforded by sunscreen application. , 29
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23448
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034532769&partnerID=MN8TOARS
Jenkins, G., Parry, J., & Jenkins, G. (2000). Restriction site mutation (RSM) analysis of 2-acetylaminofluorene (2-AAF)-induced mouse liver mutations and comparison with the measurement of in vivo micronucleus induction in the bone marrows of (2-AAF)-treated mice. Teratogenesis, Carcinogenesis, and Mutagenesis, 20(3), 107-117.
https://doi.org/10.1002/(SICI)1520-6866(2000)20:3<107::AID-TCM2>3.0.CO;2-8, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23447
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034032807&partnerID=MN8TOARS
Jenkins, G., Burlinson, B., Parry, J., & Jenkins, G. (2000). The polymerase inhibition assay: A methodology for the identification of DNA-damaging agents. Molecular Carcinogenesis, 27(4), 289-297.
https://doi.org/10.1002/(SICI)1098-2744(200004)27:4<289::AID-MC7>3.0.CO;2-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23446
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034068795&partnerID=MN8TOARS
Jenkins, G., Takahashi, N., Parry, J., & Jenkins, G. (1999). A study of ENU-induced mutagenesis in the mouse using the restriction site mutation (RSM) assay. Teratogenesis, Carcinogenesis, and Mutagenesis, 19(4), 281-292.
https://doi.org/10.1002/(SICI)1520-6866(1999)19:4<281::AID-TCM5>3.0.CO;2-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23453
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032812579&partnerID=MN8TOARS
Jenkins, G., Takahashi, N., Parry, J., & Jenkins, G. (1999). Inverse restriction site mutation (iRSM) analysis. Mutation detection involving the formation of restriction enzyme sites in target genes. Mutagenesis, 14(1), 37-42.
https://doi.org/10.1093/mutage/14.1.37, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23452
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032911193&partnerID=MN8TOARS
Jenkins, G., Suzen, H., Sueiro, R., Parry, J., & Jenkins, G. (1999). The restriction site mutation assay: a review of the methodology development and the current status of the technique. Mutagenesis, 14(5), 439-448.
https://doi.org/10.1093/mutage/14.5.439, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23451
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032863977&partnerID=MN8TOARS
Jenkins, G., Takahashi, N., Parry, J., & Jenkins, G. (1999). A study of ENU‐induced mutagenesis in the mouse using the restriction site mutation (RSM) assay. Teratogenesis, Carcinogenesis, and Mutagenesis, 19(4), 281-292.
https://doi.org/10.1002/(sici)1520-6866(1999)19:4<281::aid-tcm5>3.3.co;2-0, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49721
Suzen, S., Jenkins, G., Parry, J., & Jenkins, G. (1998). Application of the restriction site mutation technique toN-methyl-N-nitrosourea-induced mutations in the rat. Teratogenesis, Carcinogenesis, and Mutagenesis, 18(4), 171-182.
https://doi.org/10.1002/(SICI)1520-6866(1998)18:4<171::AID-TCM3>3.0.CO;2-N, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23455
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031795234&partnerID=MN8TOARS
Jenkins, G., Chaleshtori, M., Song, H., Parry, J., & Jenkins, G. (1998). Mutation analysis using the restriction site mutation (RSM) assay. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 405(2), 209-220.
https://doi.org/10.1016/S0027-5107(98)00138-9, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23454
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032552631&partnerID=MN8TOARS
Suzen, S., Jenkins, G., & Parry, J. (1998). Application of the restriction site mutation technique to N‐methyl‐N‐nitrosourea‐induced mutations in the rat. Teratogenesis, Carcinogenesis, and Mutagenesis, 18(4), 171-182.
https://doi.org/10.1002/(sici)1520-6866(1998)18:4<171::aid-tcm3>3.3.co;2-e, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49722
Jenkins, G., Mitchell, I., Parry, J., & Jenkins, G. (1997). Enhanced restriction site mutation (RSM) analysis of 1,2-dimethylhydrazine induced mutations, using endogenous p53 intron sequences. Mutagenesis, 12(3), 117-123.
https://doi.org/10.1093/mutage/12.3.117, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23456
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030920275&partnerID=MN8TOARS
Jenkins, G. & Parry, J. (1997). A novel method for the construction of an internal standard molecule for quantitative PCR. Technical Tips Online, 2(1), 177-180.
https://doi.org/10.1016/s1366-2120(08)70078-3, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49723

Llyfrau Awdurol

Falk, G., Jacobson, B., Riddell, R., Rubenstein, J., El-Zimaity, H., Drewes, A., Roark, K., Sontag, S., Schnell, T., Leya, J., Chejfec, G., Richter, J., Jenkins, G., Goldman, A., Dvorak, K., Nardone, G., & Jenkins, G. (2011). Barrett's esophagus: prevalence-incidence and etiology-origins
https://doi.org/10.1111/j.1749-6632.2011.06042.x, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23415
http://www.scopus.com/inward/record.url?eid=2-s2.0-80053200904&partnerID=MN8TOARS
Jenkins, G., Johnson, G., Parry, J., Doak, S., & Jenkins, G. (2011). Genotoxic Impurities
https://doi.org/10.1002/9780470929377.ch7, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23412
http://www.scopus.com/inward/record.url?eid=2-s2.0-84886204112&partnerID=MN8TOARS
Jenkins, G. & Hardie, L. (2008). Bile Acids
https://doi.org/10.1039/9781847558336, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49718
Stamp, D., Jenkins, G., & Jenkins, G. (2008). An overview of bile-acid synthesis, chemistry and function
SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23429
http://www.scopus.com/inward/record.url?eid=2-s2.0-79960283772&partnerID=MN8TOARS
Jenkins, G. & Jenkins, G. (2008). Molecular Biomethods Handbook
https://doi.org/10.1007/978-1-60327-375-6_2, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23424
http://www.scopus.com/inward/record.url?eid=2-s2.0-84900230686&partnerID=MN8TOARS

Penodau Llyfrau

Evans, S., Jenkins, G., Doak, S., & Clift, M. (2019). Cellular Defense Mechanisms Following Nanomaterial Exposure: A Focus on Oxidative Stress and Cytotoxicity. Biological Responses to Nanoscale Particles (pp. 243-254). Springer International Publishing
https://doi.org/10.1007/978-3-030-12461-8_10, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa50127
Jenkins, G. & Cronin, J. (2008). Chapter 6. Bile Acids and Oesophageal Adenocarcinoma (OA). Bile Acids -121).
https://doi.org/10.1039/9781847558336-00100, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa23428
http://www.scopus.com/inward/record.url?eid=2-s2.0-84897485710&partnerID=MN8TOARS

Cynnyrch Ymchwil Arall

Jenkins, G. & Cronin, J. (n.d.) Bile Acids
https://doi.org/10.1039/9781847558336-00100, SU Repository: https://cronfa.swan.ac.uk/Record/cronfa49724

Goruchwyliaeth

Developing the role of radiotherapy for inoperable gastric cancer (cyfredol)

MD

Goruchwyliwr arall: Prof Hayley Hutchings
Serum Raman Spectroscopy as a disease monitoring tool during treatment for colorectal cancer (dyfarnwyd 2023)

MD

Goruchwyliwr arall: Prof Peter Dunstan
Investigating Genotoxic and Metabolic Effects of Dietary Carcinogens in Gastrointestinal and Hepatic Cell Models for a Novel 3R-Compliant In Vitro Safety Assessment (cyfredol)

PhD

Goruchwyliwr arall: Prof Shareen Doak
Mechanistic investigation of the causes of tumour induced lymphocyte DNA damage. (cyfredol)

PhD

Goruchwyliwr arall: Prof Shareen Doak
Developing quantitative Adverse Outcome Pathways (qAOPs) for genotoxicity using 3D liver models (cyfredol)

PhD

Goruchwyliwr arall: Prof Shareen Doak
Ruthenium Polypyridyl Complexes in the Exploration of the Chemical Biology of Mismatch DNA (cyfredol)

PhD

Goruchwyliwr arall: Dr Martin Gill
Using DNA damage in circulating blood cells as a biomarker for oesophageal adenocarcinoma risk (cyfredol)

PhD

Goruchwyliwr arall: Prof Shareen Doak
Novel Multiple Endpoint Approaches for Assessing Genotoxicity and Carcinogenicity Potential In Vitro (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Prof Shareen Doak
Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens (NGCs) (dyfarnwyd 2024)

PhD

Goruchwyliwr arall: Prof Shareen Doak

Modiwlau a Addysgir

PM-317 Genetics of Cancer

This module extensively explores the molecular and genetic foundations underlying key aspects of cancer, including angiogenesis, apoptosis, cell signalling, DNA damage, molecular pathology, invasion and metastasis, inflammation, and the Warburg effect. Expert insights will be shared by a consultant gastroenterologist and a consultant pathologist during select lectures. This approach aims to offer students a well-rounded understanding that integrates academic knowledge, research insights, and practical clinical expertise. Additionally, the module seeks to broaden students' perspectives by dedicating a final lecture to an individual who shares firsthand experiences of living with cancer. This unique session provides students with valuable insights into the human aspect of the disease, fostering empathy and a deeper appreciation of the patient's journey. An appreciation for the way in which an individual¿s own genome can influence diagnosis, prognosis and treatment is also included.
PM-344 Capstone Project

The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project, with guidance from an academic supervisor. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through an oral presentation and dissertation on their research findings and conclusions.
PM-M28 Nano(geno)toxicology

The field of nanotechnology is ever increasing in size, and the number of nano-sized (1-100nm) particles being produced on a daily basis is at the tonnage level. Although nanotechnology-based applications are considered to be advantageous for a plethora of human activities, the potential risks posed by human exposure to nanoparticles is a constantly developing field of research. The purpose of this module therefore is to introduce to the student to particle toxicology and how it can impact upon human health. Further to this, the students will undertake a specific practical component to complement that of the theoretical content of the module. To this extent, the students will undertake a week-long, 'mini-project', covering the major areas of nanoparticle toxicology. From this approach, it is intended that the student will experience the key practical approaches taken in the field.
PMRM04 Dissertation (Research)

This module builds on the knowledge and skills developed in teaching components in part one of their relevant programme. Students will work independently in order to critically explore and add to the evidence base for a topic of relevance to their area of study.

Grantiau a Phrosiectau Allweddol

Monitro Bio mewn Ardaloedd Llygredig yn Bangladesh 2019 - 2020

Grant hyfforddi gan y Gronfa Ymchwil Heriau Byd-eang i hyfforddi Gwyddonwyr Bangladeshaidd mewn asesu mwtaniad yn y gwaed., £10,500
Delweddu cynnwys uchel yn y gofod genotoxicity 2019 - 2023

Efrydiaeth PhD, £97,678
Marcwyr difrod DNA integredig wrth gylchredeg celloedd gwaed er mwyn canfod canser yn gynnar 2018 - 2021

Asesu a dilysu prawf gwaed ar gyfer diagnosis canser., £204,787
Datblygu dull ailadrodd-dos in vitro i ganfod carcinogenau nad ydynt yn genotocsig 2018 - 2021

Efrydiaeth PhD , £90,000

Rolau Eraill

Cyfarwyddwr Ymchwil, Ysgol Feddygaeth Prifysgol Abertawe

2013 - Presennol

Cyflwyniadau, Darlithoedd a Chynadleddau a wahoddwyd

Defnyddio'r Assay Mutation PIG-A fel Biomarker ar gyfer Canser

Chwefror 2020

Lucknow, India
Monitro Amlygiad i Garsinogenau i leihau nifer yr achosion o ganser y llwybr GI

Chwefror 2020

Dhaka, Bangladesh
Dulliau yn seiliedig ar waed ar gyfer monitro ymateb i gemotherapi

Ionawr 2020

Ysbyty Felindre, Caerdydd
Modelau meinwe 3D mewn Genotocsicoleg: budd gwirioneddol

Mai 2019

Rennes, Ffrainc

Yr Athro Gareth Jenkins

Rhif ffôn

Cyfeiriad ebost

Twitter Account

LinkedIn Account

Dolenni Ymchwil

Trosolwg

Meysydd Arbenigedd

Uchafbwyntiau Gyrfa

Uchafbwyntiau Ymchwil

Holl Ymchwil

Developing the role of radiotherapy for inoperable gastric cancer (cyfredol)

Serum Raman Spectroscopy as a disease monitoring tool during treatment for colorectal cancer (dyfarnwyd 2023)

Investigating Genotoxic and Metabolic Effects of Dietary Carcinogens in Gastrointestinal and Hepatic Cell Models for a Novel 3R-Compliant In Vitro Safety Assessment (cyfredol)

Mechanistic investigation of the causes of tumour induced lymphocyte DNA damage. (cyfredol)

Developing quantitative Adverse Outcome Pathways (qAOPs) for genotoxicity using 3D liver models (cyfredol)

Ruthenium Polypyridyl Complexes in the Exploration of the Chemical Biology of Mismatch DNA (cyfredol)

Using DNA damage in circulating blood cells as a biomarker for oesophageal adenocarcinoma risk (cyfredol)

Novel Multiple Endpoint Approaches for Assessing Genotoxicity and Carcinogenicity Potential In Vitro (dyfarnwyd 2024)

Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens (NGCs) (dyfarnwyd 2024)

PM-317 Genetics of Cancer

PM-344 Capstone Project

PM-M28 Nano(geno)toxicology

PMRM04 Dissertation (Research)

Monitro Bio mewn Ardaloedd Llygredig yn Bangladesh 2019 - 2020

Delweddu cynnwys uchel yn y gofod genotoxicity 2019 - 2023

Marcwyr difrod DNA integredig wrth gylchredeg celloedd gwaed er mwyn canfod canser yn gynnar 2018 - 2021

Datblygu dull ailadrodd-dos in vitro i ganfod carcinogenau nad ydynt yn genotocsig 2018 - 2021

Cyfarwyddwr Ymchwil, Ysgol Feddygaeth Prifysgol Abertawe

Defnyddio'r Assay Mutation PIG-A fel Biomarker ar gyfer Canser

Monitro Amlygiad i Garsinogenau i leihau nifer yr achosion o ganser y llwybr GI

Dulliau yn seiliedig ar waed ar gyfer monitro ymateb i gemotherapi

Modelau meinwe 3D mewn Genotocsicoleg: budd gwirioneddol